New Insights into the Role of Ubiquitin Networks in the Regulation of Antiapoptosis Pathways

Tomoko Asaoka, Fumiyo Ikeda

研究成果: ジャーナルへの寄稿学術誌査読

13 被引用数 (Scopus)

抄録

Ubiquitin is a small modifier protein that conjugates on lysine (Lys) residues of substrates, and it can be targeted by another ubiquitin molecule to form chains through conjugation on the intrinsic Lys residues and methionine (Met) 1 residue. Ubiquitination of substrates by such chains determines the fate of substrates, thereby influencing various biological processes. In this chapter, we focus on apoptosis with an emphasis on the regulation by ubiquitination. The signal transduction of apoptosis is governed not only by the classical function of ubiquitin, which is proteasome-dependent degradation of substrates, but also by the apoptosis signaling complex formation guided by different types of ubiquitin chains. Ubiquitinations of pro- and antiapoptotic proteins are tightly regulated by particular sets of enzymes, such as ubiquitin E3 ligases and deubiquitinases (DUBs). We further discuss ubiquitination in the tumor necrosis factor (TNF) signaling pathway as an example for the ubiquitin-dependent regulation of apoptosis and cell survival.

本文言語英語
ページ(範囲)121-158
ページ数38
ジャーナルInternational Review of Cell and Molecular Biology
318
DOI
出版ステータス出版済み - 2015
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 分子生物学
  • 細胞生物学

フィンガープリント

「New Insights into the Role of Ubiquitin Networks in the Regulation of Antiapoptosis Pathways」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル