TY - JOUR
T1 - New insights into the function and regulation of mitochondrial fission
AU - Otera, Hidenori
AU - Ishihara, Naotada
AU - Mihara, Katsuyoshi
N1 - Funding Information:
This work was supported by the Grant-in Aid for Young Scientists (B) ( JSPS 23770231 ), and grant from the Naito Foundation , the Sumitomo Foundation , the Ichiro Kanehara Foundation , the Yokoyama Foundation for Clinical Pharmacology , the Kanae Foundation , the Uehara Memorial Foundation , and the Tokyo Biochemical Research Foundation to HO; a Grant-in-aid for Young Scientists, Grant-in-aid for Scientific Research on Priority Areas , Funding Program for Next Generation World-Leading Researchers ( LS121 ), and Kato Memorial Bioscience Foundation to NI, and a Grant-in-Aid for Scientific Research (B) ( JSPS 22370071 ) and Grant-in-Aid for Challenging Exploratory Research ( JSPS 24657138 ), and Grant-in-Aid for Special Promoted Research ( JSPS 14002007 ) to KM.
PY - 2013/5
Y1 - 2013/5
N2 - Mitochondrial morphology changes dynamically by coordinated fusion and fission and cytoskeleton-based transport. Cycles of outer and inner membrane fusion and fission are required for the exchange of damaged mitochondrial genome DNA, proteins, and lipids with those of healthy mitochondria to maintain robust mitochondrial structure and function. These dynamics are crucial for cellular life and death, because they are essential for cellular development and homeostasis, as well as apoptosis. Disruption of these functions leads to cellular dysfunction, resulting in neurologic disorders and metabolic diseases. The cytoplasmic dynamin-related GTPase Drp1 plays a key role in mitochondrial fission, while Mfn1, Mfn2 and Opa1 are involved in fusion reaction. Here, we review current knowledge regarding the regulation and physiologic relevance of Drp1-dependent mitochondrial fission: the initial recruitment and assembly of Drp1 on the mitochondrial fission foci, regulation of Drp1 activity by post-translational modifications, and the role of mitochondrial fission in cell pathophysiology.
AB - Mitochondrial morphology changes dynamically by coordinated fusion and fission and cytoskeleton-based transport. Cycles of outer and inner membrane fusion and fission are required for the exchange of damaged mitochondrial genome DNA, proteins, and lipids with those of healthy mitochondria to maintain robust mitochondrial structure and function. These dynamics are crucial for cellular life and death, because they are essential for cellular development and homeostasis, as well as apoptosis. Disruption of these functions leads to cellular dysfunction, resulting in neurologic disorders and metabolic diseases. The cytoplasmic dynamin-related GTPase Drp1 plays a key role in mitochondrial fission, while Mfn1, Mfn2 and Opa1 are involved in fusion reaction. Here, we review current knowledge regarding the regulation and physiologic relevance of Drp1-dependent mitochondrial fission: the initial recruitment and assembly of Drp1 on the mitochondrial fission foci, regulation of Drp1 activity by post-translational modifications, and the role of mitochondrial fission in cell pathophysiology.
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U2 - 10.1016/j.bbamcr.2013.02.002
DO - 10.1016/j.bbamcr.2013.02.002
M3 - Review article
C2 - 23434681
AN - SCOPUS:84875273810
SN - 0167-4889
VL - 1833
SP - 1256
EP - 1268
JO - Biochimica et Biophysica Acta - Molecular Cell Research
JF - Biochimica et Biophysica Acta - Molecular Cell Research
IS - 5
ER -