New acylated triterpene saponins from Silene fortunei that modulate lymphocyte proliferation

Ghezala Gaidi, Tomofumi Miyamoto, Véronique Laurens, Marie Aleth Lacaille-Dubois

研究成果: ジャーナルへの寄稿学術誌査読

50 被引用数 (Scopus)

抄録

Three new acylated triterpene saponins 1-3, with a quillaic acid as aglycon, were isolated from the roots of Silene fortunei together with a known phytoecdysteroid (20-hydroxyecdysone). The compounds were characterized mainly by a combination of 2D NMR techniques, mass spectrometry, and chemical methods. Saponins 1-3, jenisseensosides C and D (4, 5), and 6 (deacylated form of 2/3 and 4/5) were found to stimulate the proliferation of the Jurkat tumor cell lines at low concentration. At high concentration, 2/3 and 4/5 inhibited the proliferation of the cells and suggested the induction of apoptosis.

本文言語英語
ページ(範囲)1568-1572
ページ数5
ジャーナルJournal of Natural Products
65
11
DOI
出版ステータス出版済み - 11月 2002

!!!All Science Journal Classification (ASJC) codes

  • 分析化学
  • 分子医療
  • 薬理学
  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

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