TY - GEN
T1 - Nanowires for early cancer and diabetes diagnosis via micro-RNA detection in urine extracellular vesicles
AU - Yasui, T.
AU - Takeshita, D.
AU - Yanagida, T.
AU - Kaji, N.
AU - Kanai, M.
AU - Nagashima, K.
AU - Yukawa, H.
AU - Kawai, T.
AU - Baba, Y.
N1 - Funding Information:
This research was partly supported by PRESTO, Japan Science and Technology Agency (JST), the ImPACT Program of the Council for Science, Technology and Innovation (Cabinet Office, Government of Japan), the JSPS Grant-in-Aid for Scientific Research (A) 16H02091, and Nanotechnology Platform Program (Molecule and Material Synthesis) of the Ministry of Education, Culture, Sports, Science and Technology (MEXT).
PY - 2016
Y1 - 2016
N2 - Inorganic nanowires recently show their great promise for analyzing cells or intracellular components due to the nanowires feature of a stealth effect against cell surfaces [1]. Here we showed a novel usability of the nanowires to achieve an efficient capture of extracellular vesicles, which surfaces is similar to the cell surfaces, and early diagnosis based on the vesicles microRNAs. Our methodology could achieve extracellular vesicles capture in urine over 95% within 40 min, and detect cancer- and type 2 diabetes-related microRNAs from urine samples.
AB - Inorganic nanowires recently show their great promise for analyzing cells or intracellular components due to the nanowires feature of a stealth effect against cell surfaces [1]. Here we showed a novel usability of the nanowires to achieve an efficient capture of extracellular vesicles, which surfaces is similar to the cell surfaces, and early diagnosis based on the vesicles microRNAs. Our methodology could achieve extracellular vesicles capture in urine over 95% within 40 min, and detect cancer- and type 2 diabetes-related microRNAs from urine samples.
UR - http://www.scopus.com/inward/record.url?scp=85014209095&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85014209095&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:85014209095
T3 - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
SP - 108
EP - 109
BT - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
PB - Chemical and Biological Microsystems Society
T2 - 20th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2016
Y2 - 9 October 2016 through 13 October 2016
ER -
