Nanobiodevices for single DNA and cell analysis

Nanopore-based DNA sequencing is an emerging technology that may soon overcome even the current next-generation sequencing from the viewpoint of DNA sequencing cost and throughput. In this paper, we will show that recent advances of the "pretreatment" process using various nanostructures such as nanopillars, nanowires, and nanoslits structures inside microchannel. In addition, another type of micro and nanostructures such as micro and nanometer-scale chamber array on a chip becomes a powerful new tool for bioanalysis since it could stochastically capture and measure biomolecules at a single molecule level. The applications of these chamber array structures for single cell analysis will be also described.