N-myc downstream-regulated gene 1 promotes tumor inflammatory angiogenesis through JNK activation and autocrine loop of interleukin-1α by human gastric cancer cells

Yuichi Murakami; Kosuke Watari; Tomohiro Shibata; Manami Uba; Hiroki Ureshino; Akihiko Kawahara; Hideyuki Abe; Hiroto Izumi; Naofumi Mukaida; Michihiko Kuwano; Mayumi Ono

doi:10.1074/jbc.M113.472068

N-myc downstream-regulated gene 1 promotes tumor inflammatory angiogenesis through JNK activation and autocrine loop of interleukin-1α by human gastric cancer cells

Yuichi Murakami
, Kosuke Watari
, Tomohiro Shibata
, Manami Uba
, Hiroki Ureshino
, Akihiko Kawahara
, Hideyuki Abe
, Hiroto Izumi
, Naofumi Mukaida
, Michihiko Kuwano
, Mayumi Ono

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

44 被引用数 (Scopus)

抄録

Background: Expression of N-myc downstream-regulated gene 1 (NDRG1) is significantly correlated with tumor angiogenesis by human gastric cancer. Results: NDRG1 overexpression induced JNK activation and expression of IL-1α and angiogenic CXC chemokines accompanied by tumor angiogenesis. Conclusion: NDRG1 promoted IL-1α-induced tumor angiogenesis through JNK/AP-1 activation. Significance: NDRG1/JNK/IL-1 axis could be a useful target for development of a novel anti-angiogenic strategy in gastric cancer.

本文言語	英語
ページ（範囲）	25025-25037
ページ数	13
ジャーナル	Journal of Biological Chemistry
巻	288
号	35
DOI	https://doi.org/10.1074/jbc.M113.472068
出版ステータス	出版済み - 8月 30 2013
外部発表	はい

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!!!All Science Journal Classification (ASJC) codes

生化学
分子生物学
細胞生物学

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10.1074/jbc.M113.472068

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「N-myc downstream-regulated gene 1 promotes tumor inflammatory angiogenesis through JNK activation and autocrine loop of interleukin-1α by human gastric cancer cells」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル

Murakami, Y., Watari, K., Shibata, T., Uba, M., Ureshino, H., Kawahara, A., Abe, H., Izumi, H., Mukaida, N., Kuwano, M., & Ono, M. (2013). N-myc downstream-regulated gene 1 promotes tumor inflammatory angiogenesis through JNK activation and autocrine loop of interleukin-1α by human gastric cancer cells. Journal of Biological Chemistry, 288(35), 25025-25037. https://doi.org/10.1074/jbc.M113.472068

N-myc downstream-regulated gene 1 promotes tumor inflammatory angiogenesis through JNK activation and autocrine loop of interleukin-1α by human gastric cancer cells. / Murakami, Yuichi; Watari, Kosuke; Shibata, Tomohiro その他.
In: Journal of Biological Chemistry, Vol. 288, No. 35, 30.08.2013, p. 25025-25037.

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

Murakami, Y, Watari, K, Shibata, T, Uba, M, Ureshino, H, Kawahara, A, Abe, H, Izumi, H, Mukaida, N, Kuwano, M & Ono, M 2013, 'N-myc downstream-regulated gene 1 promotes tumor inflammatory angiogenesis through JNK activation and autocrine loop of interleukin-1α by human gastric cancer cells', Journal of Biological Chemistry, vol. 288, no. 35, pp. 25025-25037. https://doi.org/10.1074/jbc.M113.472068

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abstract = "Background: Expression of N-myc downstream-regulated gene 1 (NDRG1) is significantly correlated with tumor angiogenesis by human gastric cancer. Results: NDRG1 overexpression induced JNK activation and expression of IL-1α and angiogenic CXC chemokines accompanied by tumor angiogenesis. Conclusion: NDRG1 promoted IL-1α-induced tumor angiogenesis through JNK/AP-1 activation. Significance: NDRG1/JNK/IL-1 axis could be a useful target for development of a novel anti-angiogenic strategy in gastric cancer.",

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AU - Uba, Manami

AU - Ureshino, Hiroki

AU - Kawahara, Akihiko

AU - Abe, Hideyuki

AU - Izumi, Hiroto

AU - Mukaida, Naofumi

AU - Kuwano, Michihiko

AU - Ono, Mayumi

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AB - Background: Expression of N-myc downstream-regulated gene 1 (NDRG1) is significantly correlated with tumor angiogenesis by human gastric cancer. Results: NDRG1 overexpression induced JNK activation and expression of IL-1α and angiogenic CXC chemokines accompanied by tumor angiogenesis. Conclusion: NDRG1 promoted IL-1α-induced tumor angiogenesis through JNK/AP-1 activation. Significance: NDRG1/JNK/IL-1 axis could be a useful target for development of a novel anti-angiogenic strategy in gastric cancer.

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