N-Methyl-N-nitrosourea-induced renal tumors in rats: Immunohistochemical comparison to human Wilms tumors

Katsuhiko Yoshizawa, Yuichi Kinoshita, Yuko Emoto, Ayako Kimura, Norihisa Uehara, Takashi Yuri, Nobuaki Shikata, Airo Tsubura

研究成果: ジャーナルへの寄稿学術誌査読

6 被引用数 (Scopus)

抄録

N-Methyl-N-nitrosourea (MNU)-induced renal tumors in rats and Wilms tumors in humans were compared. Renal mesenchymal tumors (RMTs) and nephroblastomas (blastemal and epithelial components) in female Lewis rats treated with a single intraperitoneal injection of 50 mg/kg MNU at birth and Wilms tumors (blastemal, epithelial and mesenchymal components) in humans were analyzed for the expression of pancytokeratin (CK), vimentin, p63, α-smooth muscle actin (SMA), desmin, S-100, CD57, CD117/c-kit, Wilms tumor 1 protein (WT1) and β-catenin. The mesenchymal components of rat RMTs and human Wilms tumors expressed vimentin, SMA and β-catenin. The blastemal components of rat nephroblastomas and human Wilms tumors expressed vimentin, CD117/c-kit and β-catenin. The epithelial components of rat nephroblastomas and human Wilms tumors expressed vimentin and β-catenin. WT1 was expressed in different cellular components of rat tumors as compared with human Wilms tumors; the expression was seen in mesenchymal tumors and blastemal components of nephroblastomas in rats and epithelial components in human Wilms tumors. CK, p63 and CD57 were not expressed in rat RMTs or nephroblastomas, while CK and WT1 were expressed in epithelial components and CD57 was expressed in blastemal and epithelial components of human Wilms tumors. Rat and human tumors were universally negative for the expression of desmin and S-100. The immunohistochemical characteristics of rat renal tumors and human Wilms tumors may provide valuable information on the differences in renal oncogenesis and biology between the two species.

本文言語英語
ページ(範囲)141-148
ページ数8
ジャーナルJournal of Toxicologic Pathology
26
2
DOI
出版ステータス出版済み - 2013
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 病理学および法医学
  • 毒物学

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