Multilayer formation of oriented helical peptides glued by hydrogen bonding

Yoshiko Miura, Guo Chun Xu, Shunsaku Kimura, Shiro Kobayashi, Mitsumasa Iwamoto, Yukio Imanishi, Junzo Umemura

研究成果: ジャーナルへの寄稿会議記事査読

13 被引用数 (Scopus)

抄録

Hydrophobic helical peptides having nucleotide base analogues were synthesized, and the helix multilayer was formed by interlayer hydrogen bonds to investigate the surface potential of the multilayer. Hydrophobic helical peptides having a diamino-triazine group at the C-terminal were incubated with the thymine-terminated self-assembled monolayer (SAM). The thin layers of helical peptides were formed with a nearly vertical orientation. The amount of peptide adsorbed on the surface increased with increasing concentration of the peptide solution at preparation, indicating multilayer formation. The numbers of helix layers were 10 and 5 for Boc-(Leu-Aib)8-T (T; 4-N-(aminoethyl)amino-2,6-diamino-1,3,5-triazine) and U-Ala-(Leu-Aib)8-T (U; 6-methyluracil), respectively, when 0.4 mM of peptide solution was used for the preparation. The surface potentials of these multilayers were, respectively, 558 mV and 500 mV. The U-Ala-(Leu-Aib)8-T multilayer generated nearly the same surface potential as the Boc-(Leu-Aib)8-T multilayer, even though the membrane thickness was different. The large positive surface potential should promote electron injection from gold to the thin peptide layer, resulting in saturation of the positive potential generation.

本文言語英語
ページ(範囲)59-65
ページ数7
ジャーナルThin Solid Films
393
1-2
DOI
出版ステータス出版済み - 8月 1 2001
外部発表はい
イベント4th International Conference on Nano-Molecular Electronics - Kobe, 日本
継続期間: 12月 5 200012月 7 2000

!!!All Science Journal Classification (ASJC) codes

  • 電子材料、光学材料、および磁性材料
  • 表面および界面
  • 表面、皮膜および薄膜
  • 金属および合金
  • 材料化学

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