Monoclonal antibody 4B4 blocks suppression of the immune response to Cryptomeria japonica pollen antigen

Sho Matsushita; Chikao Morimoto; Stuart F. Schlossman; Takehiko Sasazuki

doi:10.1016/0198-8859(88)90046-8

Monoclonal antibody 4B4 blocks suppression of the immune response to Cryptomeria japonica pollen antigen

Sho Matsushita
, Chikao Morimoto
, Stuart F. Schlossman
, Takehiko Sasazuki

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

6 被引用数 (Scopus)

抄録

The monoclonal antibody 4B4 blocked the T8⁺ T cell-mediated suppression of IgE response to Cryptomeria japonica pollen antigen (CPAg). The helper T cells for IgE response to CPAg expressed 4B4 specificity, whereas the suppressor T cells did not. The 4B4 molecule on PBL was a heterodimer and three additional bands were detected on activated CPAg-specific T4⁺ T cells. They were not closely associated with HLA molecules. It is thus conceivable that the 4B4 molecule is not only a marker of helper T cells but also has an important role in the suppressor-helper interactions in the regulation of IgE response to CPAg.

本文言語	英語
ページ（範囲）	1-7
ページ数	7
ジャーナル	Human Immunology
巻	22
号	1
DOI	https://doi.org/10.1016/0198-8859(88)90046-8
出版ステータス	出版済み - 5月 1988
外部発表	はい

!!!All Science Journal Classification (ASJC) codes

免疫アレルギー学
免疫学

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10.1016/0198-8859(88)90046-8

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@article{93c7f94b23414c2f880ac9bb3c5ef01d,

title = "Monoclonal antibody 4B4 blocks suppression of the immune response to Cryptomeria japonica pollen antigen",

abstract = "The monoclonal antibody 4B4 blocked the T8+ T cell-mediated suppression of IgE response to Cryptomeria japonica pollen antigen (CPAg). The helper T cells for IgE response to CPAg expressed 4B4 specificity, whereas the suppressor T cells did not. The 4B4 molecule on PBL was a heterodimer and three additional bands were detected on activated CPAg-specific T4+ T cells. They were not closely associated with HLA molecules. It is thus conceivable that the 4B4 molecule is not only a marker of helper T cells but also has an important role in the suppressor-helper interactions in the regulation of IgE response to CPAg.",

author = "Sho Matsushita and Chikao Morimoto and Schlossman, \{Stuart F.\} and Takehiko Sasazuki",

note = "Funding Information: ACKNOWLEDGMENT This work was supported in part by Grants-in-Aid 59480339(1984,1985,1986), 59870019(1984,1985,1986) and 60480177(1985,1986) from the Ministry of Education, Culture and Science, Japan, a Research Grant for Intractable Disease from the Ministry of Health and Welfare, Japan, and by N|H grants A| 12069, CA 19589 and AM 33713.",

year = "1988",

month = may,

doi = "10.1016/0198-8859(88)90046-8",

language = "English",

volume = "22",

pages = "1--7",

journal = "Human Immunology",

issn = "0198-8859",

publisher = "Elsevier Inc.",

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T1 - Monoclonal antibody 4B4 blocks suppression of the immune response to Cryptomeria japonica pollen antigen

AU - Matsushita, Sho

AU - Morimoto, Chikao

AU - Schlossman, Stuart F.

AU - Sasazuki, Takehiko

N1 - Funding Information: ACKNOWLEDGMENT This work was supported in part by Grants-in-Aid 59480339(1984,1985,1986), 59870019(1984,1985,1986) and 60480177(1985,1986) from the Ministry of Education, Culture and Science, Japan, a Research Grant for Intractable Disease from the Ministry of Health and Welfare, Japan, and by N|H grants A| 12069, CA 19589 and AM 33713.

PY - 1988/5

Y1 - 1988/5

N2 - The monoclonal antibody 4B4 blocked the T8+ T cell-mediated suppression of IgE response to Cryptomeria japonica pollen antigen (CPAg). The helper T cells for IgE response to CPAg expressed 4B4 specificity, whereas the suppressor T cells did not. The 4B4 molecule on PBL was a heterodimer and three additional bands were detected on activated CPAg-specific T4+ T cells. They were not closely associated with HLA molecules. It is thus conceivable that the 4B4 molecule is not only a marker of helper T cells but also has an important role in the suppressor-helper interactions in the regulation of IgE response to CPAg.

AB - The monoclonal antibody 4B4 blocked the T8+ T cell-mediated suppression of IgE response to Cryptomeria japonica pollen antigen (CPAg). The helper T cells for IgE response to CPAg expressed 4B4 specificity, whereas the suppressor T cells did not. The 4B4 molecule on PBL was a heterodimer and three additional bands were detected on activated CPAg-specific T4+ T cells. They were not closely associated with HLA molecules. It is thus conceivable that the 4B4 molecule is not only a marker of helper T cells but also has an important role in the suppressor-helper interactions in the regulation of IgE response to CPAg.

UR - https://www.scopus.com/pages/publications/0023948577

UR - https://www.scopus.com/pages/publications/0023948577#tab=citedBy

U2 - 10.1016/0198-8859(88)90046-8

DO - 10.1016/0198-8859(88)90046-8

M3 - Article

C2 - 2968965

AN - SCOPUS:0023948577

SN - 0198-8859

VL - 22

SP - 1

EP - 7

JO - Human Immunology

JF - Human Immunology

IS - 1

ER -

Monoclonal antibody 4B4 blocks suppression of the immune response to Cryptomeria japonica pollen antigen

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!!!All Science Journal Classification (ASJC) codes

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