Monoclonal antibody 4B4 blocks suppression of the immune response to Cryptomeria japonica pollen antigen

Sho Matsushita, Chikao Morimoto, Stuart F. Schlossman, Takehiko Sasazuki

研究成果: ジャーナルへの寄稿学術誌査読

5 被引用数 (Scopus)

抄録

The monoclonal antibody 4B4 blocked the T8+ T cell-mediated suppression of IgE response to Cryptomeria japonica pollen antigen (CPAg). The helper T cells for IgE response to CPAg expressed 4B4 specificity, whereas the suppressor T cells did not. The 4B4 molecule on PBL was a heterodimer and three additional bands were detected on activated CPAg-specific T4+ T cells. They were not closely associated with HLA molecules. It is thus conceivable that the 4B4 molecule is not only a marker of helper T cells but also has an important role in the suppressor-helper interactions in the regulation of IgE response to CPAg.

本文言語英語
ページ(範囲)1-7
ページ数7
ジャーナルHuman Immunology
22
1
DOI
出版ステータス出版済み - 5月 1988
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学

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