Molecular targeted therapy for leukemic stem cells

研究成果: ジャーナルへの寄稿総説査読

抄録

Acute myelogenous leukemia (AML) originates from self-renewing leukemic stem cells (LSCs), an ultimate therapeutic target for AML. LSCs play a central role in the propagation of leukemia through their unique stem cell like properties, and LSCs share the many functional molecules with their normal counterpart hematopoietic stem cells (HSCs). For the establishment of LSCs-specific therapeutic approaches, it is quite important to understand the biological differences between LSCs and HSCs. Recent, studies have succeeded in clarifying these biological differences. In this review, I would like to introduce the biological significance of LSCs and discuss the molecular targeted therapy against LSCs.

本文言語英語
ページ(範囲)811-815
ページ数5
ジャーナルNihon rinsho. Japanese journal of clinical medicine
73
5
出版ステータス出版済み - 5月 1 2015

!!!All Science Journal Classification (ASJC) codes

  • 医学(全般)

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