Molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in Alzheimer’s disease brain

Yusaku Nakabeppu

研究成果: 書籍/レポート タイプへの寄稿

17 被引用数 (Scopus)

抄録

Accumulating clinical data indicates that insulin resistance and diabetes mellitus (DM) are major risk factors for Alzheimer’s disease (AD); however, the exact mechanisms on how insulin resistance and DM act as risk factors for AD remain unclear. Recent progress in gene expression profiling of AD brains revealed that brain insulin production and insulin signaling are significantly impaired, indicating that AD brain exhibits a feature of brain diabetes with depletion of brain insulin, which causes mitochondrial dysfunction with increased oxidative stress, thereby increasing sensitivity to peripheral diabetes. Such diabetic condition in early stage of AD brain can be exacerbated by peripheral diabetes, namely, through hyperglycemia, hyperinsulinemia, or impaired insulin response. In this chapter, I reviewed mitochondrial dysfunction and oxidative stress in AD brain and discussed how those events are involved in AD pathogenesis.

本文言語英語
ホスト出版物のタイトルAdvances in Experimental Medicine and Biology
出版社Springer
ページ27-44
ページ数18
DOI
出版ステータス出版済み - 5月 7 2019

出版物シリーズ

名前Advances in Experimental Medicine and Biology
1128
ISSN(印刷版)0065-2598
ISSN(電子版)2214-8019

!!!All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学一般

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