Microarray analysis of Arabidopsis plants in response to allelochemical L-DOPA

Anna Golisz, Mami Sugano, Syuntaro Hiradate, Yoshiharu Fujii

研究成果: ジャーナルへの寄稿学術誌査読

40 被引用数 (Scopus)

抄録

Velvetbean (Mucuna pruriens) plants impede the growth of neighboring plants. One compound, 3-(3′,4′-dihydroxyphenyl)-l-alanine (l-DOPA), is responsible for the allelopathic capacity of velvetbean. This compound is an active allelochemical that decreases root growth of several plant species. In mammals, l-DOPA is a well-known therapeutic agent for the symptomatic relief of Parkinson's disease. However, its mode of action in plants is still not well understood. To address such issues, gene expression in Arabidopsis thaliana plants, which had been exposed to l-DOPA, was analyzed using DNA microarrays. After 6 h of l-DOPA exposure, the expression of 110 genes was significantly upregulated, and the expression of 69 genes was significantly downregulated. These induced genes can be divided into different functional categories, mainly on the basis of subcellular localization, metabolism, and proteins with a binding function or cofactor requirement. Based on these results, we suggest that l-DOPA acts by two mechanisms: it influences amino acid metabolism and deregulates metal homeostasis, especially that of iron, which is required for the fundamental biological processes of all organisms.

本文言語英語
ページ(範囲)231-240
ページ数10
ジャーナルPlanta
233
2
DOI
出版ステータス出版済み - 2月 2011
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 遺伝学
  • 植物科学

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