TY - JOUR
T1 - Mesodermal and Hematopoietic Differentiation from ES and iPS Cells
AU - Inoue-Yokoo, Tomoko
AU - Tani, Kenzaburo
AU - Sugiyama, Daisuke
N1 - Funding Information:
Acknowledgments We thank Dr. Koichi Akashi, Dr. Kasem Kulkeaw, Ms. Yuka Horio, Ms. Chiyo Mizuochi, Ms. WaiFeng Lim and Dr. Elise Larmar for research support, and grant supports from the Ministry of Education, Culture, Sports, Science and Technology, the Ministry of Health, Labor and Welfare, and the Japan Society for the Promotion of Science.
PY - 2013/8
Y1 - 2013/8
N2 - Embryonic stem (ES) and induced pluripotent stem (iPS) cells can differentiate into any type of tissue when grown in a suitable culture environment and are considered valuable tools for regenerative medicine. In the field of hematology, generation of hematopoietic stem cells (HSCs) and mature hematopoietic cells (HCs) from ES and iPS cells through mesodermal cells, the ancestors of HCs, can facilitate transplantation and transfusion therapy. Several studies report generation of functional HCs from both mouse and human ES and iPS cells. This approach will likely be applied to individual patient-derived iPS cells for regenerative medicine approaches and drug screening in the future. Here, we summarize current studies of HC-generation from ES and iPS cells.
AB - Embryonic stem (ES) and induced pluripotent stem (iPS) cells can differentiate into any type of tissue when grown in a suitable culture environment and are considered valuable tools for regenerative medicine. In the field of hematology, generation of hematopoietic stem cells (HSCs) and mature hematopoietic cells (HCs) from ES and iPS cells through mesodermal cells, the ancestors of HCs, can facilitate transplantation and transfusion therapy. Several studies report generation of functional HCs from both mouse and human ES and iPS cells. This approach will likely be applied to individual patient-derived iPS cells for regenerative medicine approaches and drug screening in the future. Here, we summarize current studies of HC-generation from ES and iPS cells.
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U2 - 10.1007/s12015-012-9388-1
DO - 10.1007/s12015-012-9388-1
M3 - Article
C2 - 22684542
AN - SCOPUS:84881609101
SN - 1550-8943
VL - 9
SP - 422
EP - 434
JO - Stem Cell Reviews and Reports
JF - Stem Cell Reviews and Reports
IS - 4
ER -
