Membrane-bound transporter controls the circadian transcription of clock genes in Drosophila

Taichi Q. Itoh, Teiichi Tanimura, Akira Matsumoto

研究成果: ジャーナルへの寄稿学術誌査読

25 被引用数 (Scopus)


Little is known about molecular mechanisms that control the Drosophila circadian clock beyond the transcriptional-translational feedback regulation of clock genes as an intracellular process. In this study, Early gene at 23 (E23) was identified as a novel clock gene that encodes the membrane-bound ABC transporter that is induced by the molting hormone ecdysone. E23 expresses in pacemaker neurons in fly head, and its knockdown flies lengthened circadian period with an increased expression of the clock gene vrille. E23 and vrille responded to both ecdysone and clock signals, whereas E23 protein specifically suppressed the ecdysone response and is necessary for rhythmicity. Thus, E23 forms its own feedback loop in the ecdysone response to control circadian oscillation through ecdysone-mediated vrille expression. The ecdysone signaling pathway with E23 is essential not only in developmental stage but also for the circadian behavior in adult fly.

ジャーナルGenes to Cells
出版ステータス出版済み - 12月 2011

!!!All Science Journal Classification (ASJC) codes

  • 遺伝学
  • 細胞生物学


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