Mechanobiological signal transduction in differentiating chondrocyte and new configuration for mechanical stress culture

Ichiro Takahashi, Taisuke Masuda, Fumihito Arai, Takahisa Anada, Toshio Fukuda, Osamu Suzuki, Teruko Takano-Yamamoto

研究成果: 書籍/レポート タイプへの寄稿会議への寄与

抄録

Musculoskeletal system regulates and supports mammalian body movement by generating force and by resisting to the force exerted on the body. Skeletal tissues, bone, cartilage, muscle and tendon are mechano-responsive tissues consisted of osteoblasts, chondrocytes, myocytes and fibroblasts and their specific extracellular matrices (ECMs). Mechanical stress presents a variety of effects on the metabolism and differentiation state of these cells. During bone growth, growth plate cartilage plays a pivotal role in growth in length of bone by providing templates consisted of cartilage specific ECM, which is replaced by bone. Chondrocytes, form cartilage in synovial joints and growth plates, respond to compressive force by activating their metabolism and progressing differentiation, while tensile stimulation inhibits their differentiation. Mechanical stimulation is translated into intracellular signaling, which regulates the differentiation state and metabolism of chondrocytes. To analyze the mechanobiological response, we have been developing mechanical stress culture device. Here, we present the mechanical stress culture device and mechnobiological response of differentiating chondrocytes to stretch stimulation

本文言語英語
ホスト出版物のタイトルProceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007
ページ1061-1064
ページ数4
DOI
出版ステータス出版済み - 2007
外部発表はい
イベント2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007 - Bangkok, タイ
継続期間: 1月 16 20071月 19 2007

出版物シリーズ

名前Proceedings of the 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007

その他

その他2007 2nd IEEE International Conference on Nano/Micro Engineered and Molecular Systems, IEEE NEMS 2007
国/地域タイ
CityBangkok
Period1/16/071/19/07

!!!All Science Journal Classification (ASJC) codes

  • コンピュータ ネットワークおよび通信
  • コンピュータ サイエンスの応用
  • 電子工学および電気工学

フィンガープリント

「Mechanobiological signal transduction in differentiating chondrocyte and new configuration for mechanical stress culture」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル