TY - JOUR
T1 - Maternal exposure to fine particulate matter over the first trimester and umbilical cord insertion abnormalities
AU - Michikawa, Takehiro
AU - Morokuma, Seiichi
AU - Takeda, Yuki
AU - Yamazaki, Shin
AU - Nakahara, Kazushige
AU - Takami, Akinori
AU - Yoshino, Ayako
AU - Sugata, Seiji
AU - Saito, Shinji
AU - Hoshi, Junya
AU - Kato, Kiyoko
AU - Nitta, Hiroshi
AU - Nishiwaki, Yuji
N1 - Funding Information:
The authors thank Ms Masami Matsushita and Ms Emi Yamazaki (Department of Environmental and Occupational Health, School of Medicine, Toho University) for their research assistance. The PM2.5 components data were provided by Type II joint research between the National Institute for Environmental Studies and the local environmentalresearch institutes in Japan.
Publisher Copyright:
© 2021 The Author(s) 2021; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.
PY - 2022/2/1
Y1 - 2022/2/1
N2 - Our hypothesis was that exposure to fine particulate matter (PM2.5) is related to abnormal cord insertion, which is categorized as a form of placental implantation abnormality. We investigated the association between exposure to total PM2.5 and its chemical components over the first trimester and abnormal cord insertion, which contributes to the occurrence of adverse birth outcomes. Methods: From the Japan Perinatal Registry Network database, we used data on 83 708 women who delivered singleton births at 39 cooperating hospitals in 23 Tokyo wards (2013-2015). We collected PM2.5 on a filter and measured daily concentrations of carbon and ion components. Then, we calculated the average concentrations over the first trimester (0-13 weeks of gestation) for each woman. A multilevel logistic-regression model with the hospital as a random effect was used to estimate the odds ratios (ORs) of abnormal cord insertion. Results: Among the 83 708 women (mean age at delivery = 33.7 years), the frequency of abnormal cord insertion was 4.5%, the median concentration [interquartile range (IQR)] of total PM2.5 was 16.1 (3.61) μg/m3 and the OR per IQR for total PM2.5 was 1.14 (95% confidence interval = 1.06-1.23). In the total PM2.5-adjusted models, total carbon, organic carbon, nitrate, ammonium and chloride were positively associated with abnormal insertion. Organic carbon was consistently, and nitrate tended to be, associated with specific types of abnormal insertion (marginal or velamentous cord insertion). Conclusions: Exposure to total PM2.5 and some of its components over the first trimester increased the likelihood of abnormal cord insertion.
AB - Our hypothesis was that exposure to fine particulate matter (PM2.5) is related to abnormal cord insertion, which is categorized as a form of placental implantation abnormality. We investigated the association between exposure to total PM2.5 and its chemical components over the first trimester and abnormal cord insertion, which contributes to the occurrence of adverse birth outcomes. Methods: From the Japan Perinatal Registry Network database, we used data on 83 708 women who delivered singleton births at 39 cooperating hospitals in 23 Tokyo wards (2013-2015). We collected PM2.5 on a filter and measured daily concentrations of carbon and ion components. Then, we calculated the average concentrations over the first trimester (0-13 weeks of gestation) for each woman. A multilevel logistic-regression model with the hospital as a random effect was used to estimate the odds ratios (ORs) of abnormal cord insertion. Results: Among the 83 708 women (mean age at delivery = 33.7 years), the frequency of abnormal cord insertion was 4.5%, the median concentration [interquartile range (IQR)] of total PM2.5 was 16.1 (3.61) μg/m3 and the OR per IQR for total PM2.5 was 1.14 (95% confidence interval = 1.06-1.23). In the total PM2.5-adjusted models, total carbon, organic carbon, nitrate, ammonium and chloride were positively associated with abnormal insertion. Organic carbon was consistently, and nitrate tended to be, associated with specific types of abnormal insertion (marginal or velamentous cord insertion). Conclusions: Exposure to total PM2.5 and some of its components over the first trimester increased the likelihood of abnormal cord insertion.
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U2 - 10.1093/ije/dyab192
DO - 10.1093/ije/dyab192
M3 - Article
C2 - 34524459
AN - SCOPUS:85125001600
SN - 0300-5771
VL - 51
SP - 191
EP - 201
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
IS - 1
ER -