Macrophage Ia Expression in Athymic Nude versus Neonatally Thymectomized Mice

T. Koga, M. Mitsuyama, Y. Watanabe, Y. Yoshikai, K. Nomoto

研究成果: ジャーナルへの寄稿学術誌査読

1 被引用数 (Scopus)

抄録

The requirement of the thymus for the production of la-inducing lymphokine was studied in athymic nude, neonatally thymectomized (NTx), and sham-operated (Sham) miceThe peritoneal macrophages from NTx mice immunized with viable Listeria monocytogenes 14 days previously contained as high a proportion of la-bearing macrophages as those from Sham mice, while those from athymic nude mice contained only a small proportionIntraperitoneal injection of a culture supernatant derived from immune spleen cells of NTx mice induced Iarich exudates in recipient normal mice just as well as did a corresponding supernatant from cells of Sham mice, but that from cells of athymic nude did notThe production of la-inducing lymphokine in culture supernatants of immune spleen cells from both NTx and Sham mice was abolished by pretreatment of cells with anti-Thy-1.2 antibody plus complementThese results suggest that a T cell subset responsible for the production of la-inducing lymphokine requires the presence of the thymus for just a short period in the ontogenic development.

本文言語英語
ページ(範囲)67-76
ページ数10
ジャーナルImmunobiology
171
1-2
DOI
出版ステータス出版済み - 1986
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学
  • 血液学

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