Lymphoproliferative Disorder in an Esophageal Cancer Patient Treated with Pembrolizumab

Takashi Matsumura; Kenji Tsuchihashi; Takeo Yamamoto; Fumiaki Jinnouchi; Wataru Kusano; Yota Kusumoto; Kohei Arimizu; Hirofumi Ohmura; Yuki Kuma; Shohei Moriyama; Kyoko Yamaguchi; Mamoru Ito; Taichi Isobe; Hiroshi Ariyama; Yoshinao Oda; Koichi Akashi; Eishi Baba

doi:10.2169/internalmedicine.3743-24

Lymphoproliferative Disorder in an Esophageal Cancer Patient Treated with Pembrolizumab

Takashi Matsumura, Kenji Tsuchihashi, Takeo Yamamoto, Fumiaki Jinnouchi, Wataru Kusano, Yota Kusumoto, Kohei Arimizu, Hirofumi Ohmura, Yuki Kuma, Shohei Moriyama, Kyoko Yamaguchi, Mamoru Ito, Taichi Isobe, Hiroshi Ariyama, Yoshinao Oda, Koichi Akashi, Eishi Baba

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

1 被引用数 (Scopus)

抄録

A 75-year-old man diagnosed with esophageal cancer and lung metastasis received a combination of fluorouracil, cisplatin, and pembrolizumab. During pembrolizumab maintenance therapy, lymphoproliferative lesions at the lips and mouth and multiple lymph node swellings appeared. Histologically, Epstein-Barr virus (EBV)-encoded RNA was positive, and EBV-DNA was detected in the blood. The patient was diagnosed with other iatrogenic immunodeficiency-associated lymph proliferative disorders (OIIA-LPDs) related to EBV activation induced by pembrolizumab. Rituximab was administered, resulting in the improvement of the OIIA-LPD. The emergence of an OIIA-LPD merits close attention in patients receiving immune checkpoint inhibitors.

本文言語	英語
ページ（範囲）	1728-1732
ページ数	5
ジャーナル	Internal Medicine
巻	64
号	11
DOI	https://doi.org/10.2169/internalmedicine.3743-24
出版ステータス	出版済み - 2025

!!!All Science Journal Classification (ASJC) codes

内科学

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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10.2169/internalmedicine.3743-24

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Matsumura, T., Tsuchihashi, K., Yamamoto, T., Jinnouchi, F., Kusano, W., Kusumoto, Y., Arimizu, K., Ohmura, H., Kuma, Y., Moriyama, S., Yamaguchi, K., Ito, M., Isobe, T., Ariyama, H., Oda, Y., Akashi, K., & Baba, E. (2025). Lymphoproliferative Disorder in an Esophageal Cancer Patient Treated with Pembrolizumab. Internal Medicine, 64(11), 1728-1732. https://doi.org/10.2169/internalmedicine.3743-24

Matsumura, T, Tsuchihashi, K , Yamamoto, T , Jinnouchi, F, Kusano, W, Kusumoto, Y, Arimizu, K, Ohmura, H, Kuma, Y, Moriyama, S, Yamaguchi, K , Ito, M , Isobe, T, Ariyama, H, Oda, Y , Akashi, K & Baba, E 2025, 'Lymphoproliferative Disorder in an Esophageal Cancer Patient Treated with Pembrolizumab', Internal Medicine, vol. 64, no. 11, pp. 1728-1732. https://doi.org/10.2169/internalmedicine.3743-24

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abstract = "A 75-year-old man diagnosed with esophageal cancer and lung metastasis received a combination of fluorouracil, cisplatin, and pembrolizumab. During pembrolizumab maintenance therapy, lymphoproliferative lesions at the lips and mouth and multiple lymph node swellings appeared. Histologically, Epstein-Barr virus (EBV)-encoded RNA was positive, and EBV-DNA was detected in the blood. The patient was diagnosed with other iatrogenic immunodeficiency-associated lymph proliferative disorders (OIIA-LPDs) related to EBV activation induced by pembrolizumab. Rituximab was administered, resulting in the improvement of the OIIA-LPD. The emergence of an OIIA-LPD merits close attention in patients receiving immune checkpoint inhibitors.",

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AU - Matsumura, Takashi

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AU - Yamamoto, Takeo

AU - Jinnouchi, Fumiaki

AU - Kusano, Wataru

AU - Kusumoto, Yota

AU - Arimizu, Kohei

AU - Ohmura, Hirofumi

AU - Kuma, Yuki

AU - Moriyama, Shohei

AU - Yamaguchi, Kyoko

AU - Ito, Mamoru

AU - Isobe, Taichi

AU - Ariyama, Hiroshi

AU - Oda, Yoshinao

AU - Akashi, Koichi

AU - Baba, Eishi

PY - 2025

Y1 - 2025

N2 - A 75-year-old man diagnosed with esophageal cancer and lung metastasis received a combination of fluorouracil, cisplatin, and pembrolizumab. During pembrolizumab maintenance therapy, lymphoproliferative lesions at the lips and mouth and multiple lymph node swellings appeared. Histologically, Epstein-Barr virus (EBV)-encoded RNA was positive, and EBV-DNA was detected in the blood. The patient was diagnosed with other iatrogenic immunodeficiency-associated lymph proliferative disorders (OIIA-LPDs) related to EBV activation induced by pembrolizumab. Rituximab was administered, resulting in the improvement of the OIIA-LPD. The emergence of an OIIA-LPD merits close attention in patients receiving immune checkpoint inhibitors.

AB - A 75-year-old man diagnosed with esophageal cancer and lung metastasis received a combination of fluorouracil, cisplatin, and pembrolizumab. During pembrolizumab maintenance therapy, lymphoproliferative lesions at the lips and mouth and multiple lymph node swellings appeared. Histologically, Epstein-Barr virus (EBV)-encoded RNA was positive, and EBV-DNA was detected in the blood. The patient was diagnosed with other iatrogenic immunodeficiency-associated lymph proliferative disorders (OIIA-LPDs) related to EBV activation induced by pembrolizumab. Rituximab was administered, resulting in the improvement of the OIIA-LPD. The emergence of an OIIA-LPD merits close attention in patients receiving immune checkpoint inhibitors.

KW - EBV

KW - immune checkpoint inhibitor

KW - lymph proliferative disorders

KW - pembrolizumab

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JO - Internal Medicine

JF - Internal Medicine

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Lymphoproliferative Disorder in an Esophageal Cancer Patient Treated with Pembrolizumab

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!!!All Science Journal Classification (ASJC) codes

UN SDG

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