Lycium schweinfurthii: new secondary metabolites and their cytotoxic activities

Ahmed Elbermawi, Ahmed F. Halim, El Sayed S. Mansour, Kadria F. Ahmad, Marwa Elsbaey, Ahmed Ashour, Yhiya Amen, Mohammed M. El-Gamil, Miyamoto Tomofumi, Kuniyoshi Shimizu

研究成果: ジャーナルへの寄稿学術誌査読

7 被引用数 (Scopus)

抄録

Two new compounds, 11S-methoxy-11,12-dihydro phytuberin (2) and 9S-methoxy-benzocyclononan-7-one (6), together with twenty-six known ones were isolated from Lycium schweinfurthii (Solanaceae). Their planar structure was established by extensive spectroscopic analyses. The absolute configuration of compound 6 was determined by time dependent density functional theory calculations (TDDFT). The cytotoxic potential of the isolates was assessed in cultured skin cancer (G-361) and colon cancer (HCT-116 and CaCo-2) cell lines. Certain flavonoids showed the highest cytotoxic activity, with IC50 values ranging from 7.1 to 63.3µM; meanwhile 5-flurouracil showed IC50 values ranging from 62.4 to >100 µM. All compounds showed minimal toxicity towards normal cells from skin (NHDF-4) and colon (CCD-841), indicating their potential selectivity and safety as cytotoxic candidates.

本文言語英語
ページ(範囲)5134-5141
ページ数8
ジャーナルNatural Product Research
36
20
DOI
出版ステータス出版済み - 2022

!!!All Science Journal Classification (ASJC) codes

  • 分析化学
  • 生化学
  • 植物科学
  • 有機化学

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