Long-term follow-up status of patients with neuroblastoma after undergoing either aggressive surgery or chemotherapy - A single institutional study

Masayuki Kubota, Minoru Yagi, Satoshi Kanada, Naoki Okuyama, Yoshiaki Kinoshita, Satoru Yamazaki, Keiko Asami, Atsushi Ogawa, Teruhiro Watanabe

研究成果: ジャーナルへの寄稿学術誌査読

23 被引用数 (Scopus)

抄録

Background/Purpose Before adopting a national protocol of aggressive chemotherapy for patients with advanced neuroblastoma in 1985, the treatment strategies in use varied considerably among the institutions in Japan. An aggressive surgical resection was the treatment of choice at the authors' institution before 1985. To better understand treatment-related complications, the authors retrospectively investigated the long-term morbidity of patients who had reached adulthood. Methods Sixteen patients with neuroblastoma currently 18 years of age or older were incorporated into the study. All were non-mass screening cases, and 13 of the patients had undergone aggressive surgery, whereas the remaining 3 cases had received aggressive chemotherapy. Results In the 13 patients who had undergone aggressive surgical treatment, a unilateral atrophy of the kidney was noted in 2 cases of adrenal and retroperitoneal neuroblastomas, respectively. Dry ejaculation was noted in one case of a giant presacral neuroblastoma. A maldevelopment of the unilateral lower extremity was also noted in another case with a presacral tumor, which had been resected by abdominal and sacral approaches. In the 3 patients who had undergone aggressive chemotherapy, severe hearing loss occurred in 2 cases. However, social adaptation was well preserved in all 16 cases. Conclusions Treatment-specific complications were found in both the aggressive surgery and chemotherapy groups. These results should, therefore, be taken into account when developing future treatment protocols.

本文言語英語
ページ(範囲)1328-1332
ページ数5
ジャーナルJournal of Pediatric Surgery
39
9
DOI
出版ステータス出版済み - 9月 2004

!!!All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康
  • 外科

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