Locally synchronized synaptic inputs

Naoya Takahashi, Kazuo Kitamura, Naoki Matsuo, Mark Mayford, Masanobu Kano, Norio Matsuki, Yuji Ikegaya

研究成果: ジャーナルへの寄稿学術誌査読

234 被引用数 (Scopus)

抄録

Synaptic inputs on dendrites are nonlinearly converted to action potential outputs, yet the spatiotemporal patterns of dendritic activation remain to be elucidated at single-synapse resolution. In rodents, we optically imaged synaptic activities from hundreds of dendritic spines in hippocampal and neocortical pyramidal neurons ex vivo and in vivo. Adjacent spines were frequently synchronized in spontaneously active networks, thereby forming dendritic foci that received locally convergent inputs from presynaptic cell assemblies. This precise subcellular geometry manifested itself during N-methyl-D-aspartate receptor - dependent circuit remodeling. Thus, clustered synaptic plasticity is innately programmed to compartmentalize correlated inputs along dendrites and may reify nonlinear synaptic integration.

本文言語英語
ページ(範囲)353-356
ページ数4
ジャーナルScience
335
6066
DOI
出版ステータス出版済み - 1月 20 2012
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 一般

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