Involvement of caveolin-2 in caveolar biogenesis in MDCK cells

Ulla Lahtinen, Masanori Honsho, Robert G. Parton, Kai Simons, Paul Verkade

研究成果: ジャーナルへの寄稿学術誌査読

61 被引用数 (Scopus)

抄録

Caveolins have been identified as key components of caveolae, specialized cholesterol-enriched raft domains visible as small flask-shaped invaginations of the plasma membrane. In polarized MDCK cells caveolin-1 and -2 are found together on basolateral caveolae whereas the apical membrane, where only caveolin-1 is present, lacks caveolae. Expression of a caveolin mutant prevented the formation of the large caveolin-1/-2 hetero-oligomeric complexes, and led to intracellular retention of caveolin-2 and disappearance of caveolae from the basolateral membrane. Correspondingly, in MDCK cells over-expressing caveolin-2 the basolateral membrane exhibited an increased number of caveolae. These results indicate the involvement of caveolin-2 in caveolar biogenesis.

本文言語英語
ページ(範囲)85-88
ページ数4
ジャーナルFEBS Letters
538
1-3
DOI
出版ステータス出版済み - 3月 13 2003
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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