Investigation of the effect of microflow reactor diameter on condensation reactions in l-proline-immobilized polymer monoliths

研究成果: ジャーナルへの寄稿学術誌査読

3 被引用数 (Scopus)

抄録

The effect of monolith structure and monolith reactor inner diameter on the residence time distribution (RTD), and the relationship between RTD and the catalytic efficiency of the asymmetric aldol addition reaction between p-nitrobenzaldehyde and cyclohexanone were examined. A monolith column containing l-proline as a catalyst was prepared using poly(ethylene glycol) (PEG) as the porogen. The monolith column prepared with PEG with a molecular weight of 6000 Da displayed a narrow pore size distribution and showed a controlled RTD. The performance of monolith reactors with different inner diameters (micro- and millireactors, 0.53 and 4.00 mm) was compared: the microreactor displayed a narrower RTD and a higher turnover number for the asymmetric aldol addition reaction than the millireactor. The different linear flow velocities in the microreactor did not affect the catalytic reaction efficiency and enantioselectivity, demonstrating that the RTDs can be controlled regardless of the flow velocity.

本文言語英語
ページ(範囲)55-60
ページ数6
ジャーナルReaction Chemistry and Engineering
7
1
DOI
出版ステータス出版済み - 1月 2022

!!!All Science Journal Classification (ASJC) codes

  • 触媒
  • 化学(その他)
  • 化学工学(その他)
  • プロセス化学およびプロセス工学
  • 流体および伝熱

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