Intramuscular interferon beta-1a is effective in Japanese patients with relapsing-remitting multiple sclerosis: A pre-treatment versus treatment comparison study of gadolinium-enhanced MRI brain lesions

Takahiko Saida, Yasuto Itoyama, Kunio Tashiro, Jun Ichi Kira, Qi Hao

研究成果: ジャーナルへの寄稿学術誌査読

10 被引用数 (Scopus)

抄録

Background and objective: Interferon beta (IFNβ) is standard therapy for multiple sclerosis (MS). The efficacy of intramuscular (IM) IFNβ-1a (AVONEX®) was assessed in 25 Japanese patients with relapsingremitting MS (RRMS). Methods: Patients with RRMS not previously treated with IFNβ or other disease-modifying therapies were included in this 36-week study. The primary outcome was the average total number of gadolinium-enhanced lesions detected on four brain MRI scans during the last 12 weeks of 24 weeks treatment with IM IFNβ-1a 30 μg once weekly compared with the number during the 12-week pre-treatment period. Lesions were counted by blinded investigators. Results: IM IFNβ-1a significantly decreased the median number of gadolinium-enhanced lesions from 2.5 to 0.3 (p ≤ 0.0001) compared with pre-treatment values. The median number of new gadolinium-enhanced lesions also decreased significantly from 2.0 to 0.3 (p = 0.0002). Serum neopterin was induced in a manner similar to that observed previously in a Caucasian RRMS population. No new adverse events occurred during the study. Conclusion: This first study of IM IFNβ-1a in Japanese patients with RRMS demonstrated a level of efficacy similar to that reported in Caucasian patients based on an assessment of pre-treatment and post-treatment gadolinium-enhanced lesions.

本文言語英語
ページ(範囲)1782-1790
ページ数9
ジャーナルMultiple Sclerosis Journal
18
12
DOI
出版ステータス出版済み - 12月 2012

!!!All Science Journal Classification (ASJC) codes

  • 神経学
  • 臨床神経学

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