Intragastric administration of allyl isothiocyanate increases carbohydrate oxidation via TRPV1 but not TRPV1 in mice

Noriyuki Mori, Fuminori Kawabata, Shigenobu Matsumura, Hiroshi Hosokawa, Shigeo Kobayashi, Kazuo Inoue, Tohru Fushiki

研究成果: ジャーナルへの寄稿学術誌査読

26 被引用数 (Scopus)

抄録

The transient receptor potential (TRP) channel family is composed of a wide variety of cation-permeable channels activated polymodally by various stimuli and is implicated in a variety of cellular functions. Recent investigations have revealed that activation of TRP channels is involved not only in nociception and thermosensation but also in thermoregulation and energy metabolism. We investigated the effect of intragastric administration of TRP channel agonists on changes in energy substrate utilization of mice. Intragastric administration of allyl isothio-cyanate (AITC; a typical TRPA1 agonist) markedly increased carbohydrate oxidation but did not affect oxygen consumption. To examine whether TRP channels mediate this increase in carbohydrate oxidation, we used TRPA1 and TRPV1 knockout (KO) mice. Intra-gastric administration of AITC increased carbohydrate oxidation in TRPA1 KO mice but not in TRPV1 KO mice. Furthermore, AITC dose-dependently increased intracellular calcium ion concentration in cells expressing TRPV1. These findings suggest that AITC might activate TRPV1 and that AITC increased carbohydrate oxidation via TRPV1.

本文言語英語
ページ(範囲)1494-1505
ページ数12
ジャーナルAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
300
6
DOI
出版ステータス出版済み - 6月 2011
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生理学
  • 生理学(医学)

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