Intracoronary Artery Gene Transfer Using the REMEDY Catheter: Case Studies in Pigs and Humans

Ryo Gotoh, Jun Ichi Suzuki, Hiroshi Ito, Kensuke Egashira, Ryuichi Morishita, Mitsuaki Isobe

研究成果: ジャーナルへの寄稿学術誌査読


Background: Various approaches for the prevention of restenosis after balloon angioplasty have been proposed. Local gene transfer is one of the most anticipated procedures. We used the channel balloon, REMEDY™ as a local gene delivery balloon applying for clinical use. Methods: First, we administered an FITC labeled cis-element 'decoy' to porcine coronary arteries using the REMEDY after balloon inflation. We examined the balloon delivery and gene transduction performance under various situations. Next, we administered an NFκ B decoy to human coronary arteries using the catheter after stent implantation. Results: We detected fluorescence in the vessel wall with or without denudation before decoy administration and certified crossability in the porcine coronary arteries. In two clinical cases after stent implantation, major complications including dissection and thrombus occlusion, did not occur and the procedure was uneventful. Conclusion: The REMEDY channel balloon is a safe and useful device for delivering genes to coronary arteries, and enables efficient vascular gene transfer.

ジャーナルJapanese Journal of Interventional Cardiology
出版ステータス出版済み - 2004

!!!All Science Journal Classification (ASJC) codes

  • 放射線学、核医学およびイメージング
  • 循環器および心血管医学


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