TY - JOUR
T1 - Interleukin-8 participates in angiogenesis in non-small cell, but not small cell carcinoma of the lung
AU - Yatsunami, Jun
AU - Tsuruta, Nobuko
AU - Ogata, Kenichi
AU - Wakamatsu, Kentaro
AU - Takayama, Koichi
AU - Kawasaki, Masayuki
AU - Nakanishi, Yoichi
AU - Hara, Nobuyuki
AU - Hayashi, Shin Ichiro
PY - 1997/11/25
Y1 - 1997/11/25
N2 - We examined interleukin-8 (IL-8) production in 17 lung cancer cell lines, IL-8 expression in tumor specimens and IL-8's contribution to tumor-induced angiogenesis in vivo. Eight of 13 non-small cell lung cancer cell lines constitutively produced high levels of IL-8. Four small cell lung cancer cell lines produced little or no IL-8. Immunohistochemical analysis of transbronchial biopsy specimens revealed IL-8 staining within adenocarcinomas (22/32), squamous cell carcinomas (12/21) and large cell carcinomas (2/3), but not within most small cell carcinomas (1/22). Anti-IL-8 antisera blocked tumor angiogenesis by two IL-8 producing cell lines in a mouse model.
AB - We examined interleukin-8 (IL-8) production in 17 lung cancer cell lines, IL-8 expression in tumor specimens and IL-8's contribution to tumor-induced angiogenesis in vivo. Eight of 13 non-small cell lung cancer cell lines constitutively produced high levels of IL-8. Four small cell lung cancer cell lines produced little or no IL-8. Immunohistochemical analysis of transbronchial biopsy specimens revealed IL-8 staining within adenocarcinomas (22/32), squamous cell carcinomas (12/21) and large cell carcinomas (2/3), but not within most small cell carcinomas (1/22). Anti-IL-8 antisera blocked tumor angiogenesis by two IL-8 producing cell lines in a mouse model.
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U2 - 10.1016/S0304-3835(97)00296-6
DO - 10.1016/S0304-3835(97)00296-6
M3 - Article
C2 - 9570392
AN - SCOPUS:0030774257
SN - 0304-3835
VL - 120
SP - 101
EP - 108
JO - Cancer Letters
JF - Cancer Letters
IS - 1
ER -
