Interleukin-15 (IL-15) transgenic mice which had been inoculated with Mycobacterium bovis bacillus Calmette-Guérin (BCG) 24 weeks previously showed resistance against airborne infection with Mycobacterium tuberculosis H37Rv accompanied by an increased CD8+-Tcl-cell response. IL-15 may be used as an immune adjuvant given with BCG vaccination to enhance its biologic efficacy.
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