TY - JOUR
T1 - Inhibitory effects of extracts from Eucalyptus gunnii on α-synuclein amyloid fibrils
AU - So, Masatomo
AU - Ono, Misaki
AU - Oogai, Shigeki
AU - Kondo, Minako
AU - Yamazaki, Kaede
AU - Nachtegael, Charlotte
AU - Hamajima, Hiroshi
AU - Mutoh, Risa
AU - Kato, Masaki
AU - Kawate, Hisaya
AU - Oki, Tomoyuki
AU - Kawata, Yasushi
AU - Kumamoto, Shiho
AU - Tokui, Noritaka
AU - Takei, Toshiki
AU - Shimizu, Kuniyoshi
AU - Inoue, Akio
AU - Yamamoto, Naoki
AU - Unoki, Motoko
AU - Tanabe, Kenichi
AU - Nakashima, Kinichi
AU - Sasaki, Hiroyuki
AU - Hojo, Hironobu
AU - Nagata, Yasuo
AU - Suetake, Isao
N1 - Publisher Copyright:
© 2024 The Author(s).
PY - 2024/11/1
Y1 - 2024/11/1
N2 - Amyloid fibril formation is associated with various amyloidoses, including neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Despite the numerous studies on the inhibition of amyloid formation, the prevention and treatment of a majority of amyloid-related disorders are still challenging. In this study, we investigated the effects of various plant extracts on amyloid formation of α-synuclein. We found that the extracts from Eucalyptus gunnii are able to inhibit amyloid formation, and to disaggregate preformed fibrils, in vitro. The extract itself did not lead to cell damage. In the extract, miquelianin, which is a glycosylated form of quercetin and has been detected in the plasma and the brain, was identified and assessed to have a moderate inhibitory activity, compared to the effects of ellagic acid and quercetin, which are strong inhibitors for amyloid formation. The properties of miquelianin provide insights into the mechanisms controlling the assembly of α-synuclein in the brain.
AB - Amyloid fibril formation is associated with various amyloidoses, including neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Despite the numerous studies on the inhibition of amyloid formation, the prevention and treatment of a majority of amyloid-related disorders are still challenging. In this study, we investigated the effects of various plant extracts on amyloid formation of α-synuclein. We found that the extracts from Eucalyptus gunnii are able to inhibit amyloid formation, and to disaggregate preformed fibrils, in vitro. The extract itself did not lead to cell damage. In the extract, miquelianin, which is a glycosylated form of quercetin and has been detected in the plasma and the brain, was identified and assessed to have a moderate inhibitory activity, compared to the effects of ellagic acid and quercetin, which are strong inhibitors for amyloid formation. The properties of miquelianin provide insights into the mechanisms controlling the assembly of α-synuclein in the brain.
KW - amyloid fibril formation
KW - eucalyptus
KW - plant extracts
KW - polyphenol
KW - α-synuclein
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U2 - 10.1093/bbb/zbae114
DO - 10.1093/bbb/zbae114
M3 - Article
C2 - 39169473
AN - SCOPUS:85207461477
SN - 0916-8451
VL - 88
SP - 1289
EP - 1298
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
IS - 11
ER -