Inhibitory effects of draxin on axonal outgrowth and migration of precerebellar neurons

M. Asrafuzzaman Riyadh, Yohei Shinmyo, Kunimasa Ohta, Hideaki Tanaka

研究成果: ジャーナルへの寄稿学術誌査読

12 被引用数 (Scopus)

抄録

The rhombic lip, a dorsal stripe of the neuroepithelium lining the edge of the fourth ventricle, is the site of origin of precerebellar neurons (PCN), which migrate tangentially towards the floor plate. After reaching the floor plate, they project their axons to the cerebellum. Although previous studies have shown that the guidance molecules Netrin/DCC and Slit/Robo have critical roles in PCN migration, the molecular mechanisms underlying this process remain poorly understood. Here, we report that draxin, a repulsive axon guidance protein, is involved in PCN development. We found that draxin is expressed in the rhombic lip and migratory stream of some PCN in the developing hindbrain of mice. In addition, draxin inhibited neurite outgrowth and nuclei migration from rhombic lip explants. These results suggest that draxin functions as a repulsive guidance cue for PCN migration. However, we observed no significant differences in PCN distribution between draxin-/- and wild type embryos. Thus, draxin and other axon guidance cues may have redundant roles in PCN migration.

本文言語英語
ページ(範囲)169-174
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
449
1
DOI
出版ステータス出版済み - 6月 20 2014
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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