Inhibitory effect of artocarpanone from Artocarpus heterophyllus on melanin biosynthesis

Enos Tangke Arung, Kuniyoshi Shimizu, Ryuichiro Kondo

研究成果: ジャーナルへの寄稿学術誌査読

85 被引用数 (Scopus)

抄録

In our previous efforts to find new tyrosinase inhibitory materials, we investigated 44 Indonesian medicinal plants belonging to 24 families. Among those plants, the extract of Artocarpus heterophyllus was one of the strongest inhibitors of tyrosinase activity. By activity-guided fractionation of A. heterophyllus wood extract, we isolated artocarpanone, which inhibited both mushroom tyrosinase activity and melanin production in B16 melanoma cells. This compound is a strong candidate as a remedy for hyperpigmentation in human skin.

本文言語英語
ページ(範囲)1966-1969
ページ数4
ジャーナルBiological and Pharmaceutical Bulletin
29
9
DOI
出版ステータス出版済み - 2006

!!!All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬科学

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