Inhibition of aldose reductase in vitro by constituents of Ganoderma lucidum

Sri Fatmawati, Kuniyoshi Shimizu, Ryuichiro Kondo

研究成果: ジャーナルへの寄稿学術誌査読

29 被引用数 (Scopus)

抄録

CHCl3 extract of the fruiting body of Ganoderma lucidum was found to show inhibitory activity on human aldose reductase in vitro. From the acidic fraction, potent human aldose reductase inhibitors, ganoderic acid C2 (1) and ganoderenic acid A (2), were isolated together with three related compounds. It was found that the free carboxyl group of ganoderic acid C2 and ganoderenic acid A is essential in eliciting the inhibitory activity considering the much lower activity of their methyl esters.

本文言語英語
ページ(範囲)1691-1693
ページ数3
ジャーナルPlanta medica
76
15
DOI
出版ステータス出版済み - 2010

!!!All Science Journal Classification (ASJC) codes

  • 分析化学
  • 分子医療
  • 薬理学
  • 薬科学
  • 創薬
  • 補完代替医療
  • 有機化学

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