Influence of short-term repeated fasting on the longevity of female (NZB x NZW)F1 mice

Hiroshi Sogawa, Chiharu Kubo

研究成果: ジャーナルへの寄稿学術誌査読

35 被引用数 (Scopus)

抄録

Caloric restriction in rodents is well known to retard the rate of aging, increase mean and maximum life-spans, and inhibit the occurrence of many age-associated diseases. However, little is known about the influence of short-term repeated fasting on longevity. In this study, female (NZB x NZW)F1 mice were used to test the physiological effect of short-term repeated fasting (4 consecutive days, every 2 weeks). The results showed that fasting mice survived significantly longer than the full-fed mice, in spite of the fasting group having a heavier body weight than the control group. Mean survival times for fasting and control mice were 64.0 ± 15.3 and 47.9 ± 9.4 weeks, respectively. Short-term repeated fasting manipulation was also effective on the prolongation of life-span in autoimmune-prone mice. (C) 2000 Elsevier Science Ireland Ltd.

本文言語英語
ページ(範囲)61-71
ページ数11
ジャーナルMechanisms of Ageing and Development
115
1-2
DOI
出版ステータス出版済み - 5月 17 2000
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 加齢科学
  • 発生生物学

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