TY - JOUR
T1 - Influence of circadian-stage-dependent dosing schedule on nephrotoxicity and pharmacokinetics of isepamicin in rats
AU - Yoshiyama, Y.
AU - Nishikawa, S.
AU - Sugiyama, T.
AU - Kobayashi, T.
AU - Shimada, H.
AU - Tomonaga, F.
AU - Ohdo, S.
AU - Ogawa, N.
AU - Nakano, S.
PY - 1993
Y1 - 1993
N2 - Nephrotoxicity was more marked in rats receiving isepamicin at midlight than at middark. And, the once-daily administration at middark induced a lesser degree of nephrotoxicity than the twice-daily injection, which indicates that the once-daily treatment therapy may have potential value in the clinical use of aminoglycosides.
AB - Nephrotoxicity was more marked in rats receiving isepamicin at midlight than at middark. And, the once-daily administration at middark induced a lesser degree of nephrotoxicity than the twice-daily injection, which indicates that the once-daily treatment therapy may have potential value in the clinical use of aminoglycosides.
UR - http://www.scopus.com/inward/record.url?scp=0027291902&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027291902&partnerID=8YFLogxK
U2 - 10.1128/AAC.37.9.2042
DO - 10.1128/AAC.37.9.2042
M3 - Comment/debate
C2 - 8239630
AN - SCOPUS:0027291902
SN - 0066-4804
VL - 37
SP - 2042
EP - 2043
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 9
ER -
