TY - JOUR
T1 - Inflammation-induced tumorigenesis and metastasis
AU - Hibino, Sana
AU - Kawazoe, Tetsuro
AU - Kasahara, Hidenori
AU - Itoh, Shinji
AU - Ishimoto, Takatsugu
AU - Sakata-Yanagimoto, Mamiko
AU - Taniguchi, Koji
N1 - Funding Information:
This work is supported by JSPS KAKENHI (JP 15K21775, JP 20H03758), AMED (PRIME) under Grant Number JP 18gm6210008/19gm6210008/20gm6210008/21gm6210008, JST FOREST Program, the “Kibou Projects” Startup Support for Young Researchers in Immunology, the Keio Gijuku Academic Development Funds, the Uehara Memorial Foundation, the Kanae Foundation for the Promotion of Medical Science, the Astellas Foundation for Research on Metabolic Disorders, the SENSHIN Medical Research Foundation, research grants from Bristol Myers Squibb, the SGH foundation, the MSD Life Science Foundation, the Ichiro Kanehara Foundation for the Promotion of Medical Sciences and Medical Care, the Yasuda Medical Foundation, the Suzuken Memorial Foundation, the Pancreas Research Foundation of Japan, the Waksman Foundation of Japan Inc., the Japanese Foundation for Multidisciplinary Treatment of Cancer, Project Mirai Cancer Research Grants from the Japan Cancer Society, the Okinaka Memorial Institute for Medical Research, the Asahi Glass Foundation, the Foundation for Promotion of Cancer Research, the Kobayashi Foundation for Cancer Research, the Toray Science Foundation, the Vehicle Racing Commemorative Foundation, the JSR-Keio University Medical and Chemical Innovation Center (JKiC), a research grant from the Public Trust Surgery Research Fund, a research grant of the Princess Takamatsu Cancer Research Fund, the Tokyo Biomedical Foundation, the Daiichi Sankyo Foundation of Life Science, the Mochida Memorial Foundation for Medical and Pharmaceutical Research, the Medical Research Encouragement Prize of the Japan Medical Association, the Terumo Foundation for Life Sciences and Arts, the Yakult-Bioscience Foundation, the Novartis Foundation, the Mitsubishi Foundation, and the Takeda Science Foundation (all to K.T.), J JSPS KAKENHI (JP 19J00887, JP 19K16736), the Takeda Science Foundation, and the Kowa Life Science Foundation (all to S.H.), JSPS KAKENHI (JP 19J11357; to T.K.), JSPS KAKENHI (JP 19J00502) and the Takeda Science Foundation (all to H.K.), JSPS KAKENHI (JP 19K09198), the Medical Research Encouragement Prize of the Japan Medical Association, the Research Grant of the Princess Takamatsu Cancer Research Fund and the Takeda Science Foundation (all to S.I.), and JSPS KAKENHI (JP 20H03531; to T.I.).
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021/6/1
Y1 - 2021/6/1
N2 - Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and metastasis through various mechanisms and is now recognized as a hallmark of cancer and an attractive therapeutic target in cancer. In this review, we discuss recent advances in molecular mechanisms of how inflammation promotes tumorigenesis and metastasis and suppresses anti-tumor immunity in various types of solid tumors, including esophageal, gastric, colorectal, liver, and pancreatic cancer as well as hematopoietic malignancies.
AB - Inflammation, especially chronic inflammation, plays a pivotal role in tumorigenesis and metastasis through various mechanisms and is now recognized as a hallmark of cancer and an attractive therapeutic target in cancer. In this review, we discuss recent advances in molecular mechanisms of how inflammation promotes tumorigenesis and metastasis and suppresses anti-tumor immunity in various types of solid tumors, including esophageal, gastric, colorectal, liver, and pancreatic cancer as well as hematopoietic malignancies.
UR - http://www.scopus.com/inward/record.url?scp=85106320547&partnerID=8YFLogxK
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U2 - 10.3390/ijms22115421
DO - 10.3390/ijms22115421
M3 - Review article
C2 - 34063828
AN - SCOPUS:85106320547
SN - 1661-6596
VL - 22
JO - International journal of molecular sciences
JF - International journal of molecular sciences
IS - 11
M1 - 5421
ER -
