Induction of promotive rather than suppressive immune responses from a novel NKT cell repertoire Vα19 NKT cell with α-mannosyl ceramide analogues consisting of the immunosuppressant ISP-I as the sphingosine unit

Michio Shimamura, Naoki Okamoto, Yi Ying Huang, Jouji Yasuoka, Kenji Morita, Akira Nishiyama, Yuusuke Amano, Tadashi Mishina

研究成果: ジャーナルへの寄稿学術誌査読

13 被引用数 (Scopus)

抄録

A 2-substituted 2-aminopropane-1,3-diol or 2-aminoethanol is the minimum structure required for the immunosuppressive activity of ISP-I, an antibiotic isolated from the culture broth of Isaria sinclairil. A series of α-mannosyl ceramide (α-ManCer) analogues was derived from 2-substituted 2-aminopropane-1,3-diols or 2-aminoethanols in place of sphingosine. The newly synthesized glycosides were evaluated for their effects on immune responses. In contrast to the immunosuppressive activity of the precursors, the α-ManCer analogues induced immunopromotive responses from invariant Vα19-Jα26 transgenic mouse lymphocytes more effectively than the original α-ManCer. Collectively, it is strongly suggested that the 2-substituted 2-aminopropane-1,3-diols and 2-aminoethanols mimic sphingosine in the α-ManCer analogues so that they potentially acquire specific antigenicity toward Vα19 NKT cell, a novel NKT cell subset.

本文言語英語
ページ(範囲)569-576
ページ数8
ジャーナルEuropean Journal of Medicinal Chemistry
41
5
DOI
出版ステータス出版済み - 5月 2006
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 薬理学
  • 創薬
  • 有機化学

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