TY - JOUR
T1 - Induction of promotive rather than suppressive immune responses from a novel NKT cell repertoire Vα19 NKT cell with α-mannosyl ceramide analogues consisting of the immunosuppressant ISP-I as the sphingosine unit
AU - Shimamura, Michio
AU - Okamoto, Naoki
AU - Huang, Yi Ying
AU - Yasuoka, Jouji
AU - Morita, Kenji
AU - Nishiyama, Akira
AU - Amano, Yuusuke
AU - Mishina, Tadashi
N1 - Funding Information:
The authors thank Dr. O. Kanie for his advice. They also thank Ms. R. Fujii and Ms. N. Suzuki for help with the experiments, Mr. S. Kamijo and his group for taking care of the mice, and Ms. Y. Murakami for secretarial assistance. This work was supported by a grant from the Ministry of Health, Welfare and Labor. Japan.
PY - 2006/5
Y1 - 2006/5
N2 - A 2-substituted 2-aminopropane-1,3-diol or 2-aminoethanol is the minimum structure required for the immunosuppressive activity of ISP-I, an antibiotic isolated from the culture broth of Isaria sinclairil. A series of α-mannosyl ceramide (α-ManCer) analogues was derived from 2-substituted 2-aminopropane-1,3-diols or 2-aminoethanols in place of sphingosine. The newly synthesized glycosides were evaluated for their effects on immune responses. In contrast to the immunosuppressive activity of the precursors, the α-ManCer analogues induced immunopromotive responses from invariant Vα19-Jα26 transgenic mouse lymphocytes more effectively than the original α-ManCer. Collectively, it is strongly suggested that the 2-substituted 2-aminopropane-1,3-diols and 2-aminoethanols mimic sphingosine in the α-ManCer analogues so that they potentially acquire specific antigenicity toward Vα19 NKT cell, a novel NKT cell subset.
AB - A 2-substituted 2-aminopropane-1,3-diol or 2-aminoethanol is the minimum structure required for the immunosuppressive activity of ISP-I, an antibiotic isolated from the culture broth of Isaria sinclairil. A series of α-mannosyl ceramide (α-ManCer) analogues was derived from 2-substituted 2-aminopropane-1,3-diols or 2-aminoethanols in place of sphingosine. The newly synthesized glycosides were evaluated for their effects on immune responses. In contrast to the immunosuppressive activity of the precursors, the α-ManCer analogues induced immunopromotive responses from invariant Vα19-Jα26 transgenic mouse lymphocytes more effectively than the original α-ManCer. Collectively, it is strongly suggested that the 2-substituted 2-aminopropane-1,3-diols and 2-aminoethanols mimic sphingosine in the α-ManCer analogues so that they potentially acquire specific antigenicity toward Vα19 NKT cell, a novel NKT cell subset.
UR - http://www.scopus.com/inward/record.url?scp=33646756515&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646756515&partnerID=8YFLogxK
U2 - 10.1016/j.ejmech.2005.11.013
DO - 10.1016/j.ejmech.2005.11.013
M3 - Article
C2 - 16545892
AN - SCOPUS:33646756515
SN - 0223-5234
VL - 41
SP - 569
EP - 576
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
IS - 5
ER -