Induction of platelet-derived growth factor β-receptor in focal ischemia of rat brain

Koji Iihara, Masakiyo Sasahara, Nobuo Hashimoto, Fumitada Hazama

研究成果: ジャーナルへの寄稿学術誌査読

36 被引用数 (Scopus)

抄録

Our previous study on the ischemia-induced expression of platelet- derived growth factor (PDGF)-B chain in the rat brain prompted us to examine expression of PDGF β-receptor in the ischemic brain. Focal ischemia was induced by permanent tandem occlusion of middle cerebral and common carotid arteries in spontaneously hypertensive rats. Northern analysis revealed that ischemia significantly increased expression of the receptor in the ischemic neocortex at 4 and 7 days (328 ± 109%; 323 ± 119%, respectively, over control: n = 4, p < 0.05 versus sham). Neurons in infarct transiently showed increased immunostaining for the receptor at 1 day, whereas neurons in periinfarct area showed sustained and increased immunoreactivity from 1 to 14 days post-ischemia. Reactive glial cells in the external capsule and in molecular layer of the neocortex adjacent to infarct possessed enhanced immunoreactivity from 1 to 21 days. Furthermore, marked immunoreactivity was observed on brain macrophages in infarct and on the abluminal side of capillaries surrounding infarct from 4 to 7 days. These results demonstrated that ischemic insult increases expression of the PDGF β-receptor at both the mRNA and protein lever in the brain, suggesting its important role in cellular cascade of the ischemic brain.

本文言語英語
ページ(範囲)941-949
ページ数9
ジャーナルJournal of Cerebral Blood Flow and Metabolism
16
5
DOI
出版ステータス出版済み - 1996
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 神経学
  • 臨床神経学
  • 循環器および心血管医学

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