Indole-3-carbaldehyde: A tyrosinase inhibitor from fungus YL185

Kuniyoshi Shimizu, Xinglian Geng, Mika Hashiguchi, Hiroto Suhara, Syoko Fukunaga, Seiji Yasutake, Ryuichiro Kondo, Mototake Tsutsui, Ikuo Sato

研究成果: ジャーナルへの寄稿学術誌査読

14 被引用数 (Scopus)

抄録

Indole-3-carbaldehyde (1) was isolated as a tyrosinase inhibitor from the ethyl acetate-soluble fraction of extracellular fluids of unknown fungus YL185. The partial sequencing data of 18S ribosomal DNA (18S rDNA) indicate that this isolate belongs to the family Polyporaceae or Corticiaceae sensu lato. Indole-3-carbaldehyde inhibited the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) by mushroom tyrosinase with a 50% inhibitory concentration (IC 50) of 1.3 mM and showed inhibitory activity on melanin production in B16 melanoma cells. The aldehyde group of 1 plays an important role in eliciting tyrosinase inhibitory activity.

本文言語英語
ページ(範囲)349-354
ページ数6
ジャーナルJournal of Wood Science
49
4
DOI
出版ステータス出版済み - 2003

!!!All Science Journal Classification (ASJC) codes

  • 生体材料

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