Increased risk for CRC in diabetic patients with the nonrisk allele of SNPs at 8q24

Shinya Ishimaru, Koshi Mimori, Ken Yamamoto, Hiroshi Inoue, Seiya Imoto, Shuichi Kawano, Rui Yamaguchi, Tetsuya Sato, Hiroyuki Toh, Hisae Iinuma, Toyoki Maeda, Hideshi Ishii, Sadao Suzuki, Shinkan Tokudome, Masahiko Watanabe, Jun Ichi Tanaka, Shin Ei Kudo, Ken Ichi Sugihara, Kazuo Hase, Hidetaka MochizukiMasato Kusunoki, Kazutaka Yamada, Yasuhiro Shimada, Yoshihiro Moriya, Graham F. Barnard, Satoru Miyano, Masaki Mori

研究成果: ジャーナルへの寄稿学術誌査読

14 被引用数 (Scopus)


Background: Colorectal cancer (CRC) oncogenesis was considered to be determined by interactions between genetic and environmental factors. Specific interacting factors that influence CRC morbidity have yet to be fully investigated. Methods: A multi-institutional collaborative study with 1511 CRC patients and 2098 control subjects was used to compare the odds ratios for the occurrence of polymorphisms at 11 known single nucleotide polymorphisms (SNPs). TaqMan PCR and questionnaires were used to evaluate the effects of environmental exposures. Results: Variants of rs6983267 on 8q24 were the most significant markers of risk for CRC (odds ratio 1.16, 95% confidence interval 1.06-1.27, P = 0.0015). Non-insulindependent diabetes mellitus (DM), a higher body mass index at age 20, and meat consumption were environmental risk factors, whereas a tuna-rich diet and vitamin intake were protective factors. The cohort of rs6983267 SNP major (T) allele at 8q24 and DM had a 1.66-fold higher risk ratio than the cohort of major allele patients without DM. Conclusions: We confirmed that interactions between the genetic background and environmental factors are associated with increased risk for CRC. There is a robust risk of the minor G allele at the 8q24 rs6983267 SNP; however, a major T allele SNP could more clearly reveal a correlation with CRC specifically when DM is present.

ジャーナルAnnals of Surgical Oncology
出版ステータス出版済み - 9月 2012

!!!All Science Journal Classification (ASJC) codes

  • 外科
  • 腫瘍学


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