In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent

Tatsuhiro Yamamoto; Kenjiro Ikuta; Keiji Oi; Kohtaro Abe; Toyokazu Uwatoku; Fuminori Hyodo; Masaharu Murata; Noboru Shigetani; Kengo Yoshimitsu; Hiroaki Shimokawa; Hideo Utsumi; Yoshiki Katayama

doi:10.1016/j.bmcl.2004.03.066

In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent

Tatsuhiro Yamamoto
, Kenjiro Ikuta
, Keiji Oi
, Kohtaro Abe
, Toyokazu Uwatoku
, Fuminori Hyodo
, Masaharu Murata
, Noboru Shigetani
, Kengo Yoshimitsu
, Hiroaki Shimokawa
, Hideo Utsumi
, Yoshiki Katayama

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

16 被引用数 (Scopus)

抄録

A new class of dye-based MRI contrast agents, EB-DTPA-Gd, was designed and synthesized. The contrast agent was found to accumulate at the site of endothelial injury when the reagent was applied to isolated porcine blood vessels or in an ex vivo experiment using rat. In vivo MR detection of vascular endothelial injury was also successful in rat with its common carotid artery injured by balloon treatment. These results indicate that EB-DTPA-Gd is potentially useful for the diagnosis of vascular diseases.

本文言語	英語
ページ（範囲）	2787-2790
ページ数	4
ジャーナル	Bioorganic and Medicinal Chemistry Letters
巻	14
号	11
DOI	https://doi.org/10.1016/j.bmcl.2004.03.066
出版ステータス	出版済み - 6月 7 2004

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!!!All Science Journal Classification (ASJC) codes

生化学
分子医療
分子生物学
薬科学
創薬
臨床生化学
有機化学

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10.1016/j.bmcl.2004.03.066

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引用スタイル

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title = "In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent",

abstract = "A new class of dye-based MRI contrast agents, EB-DTPA-Gd, was designed and synthesized. The contrast agent was found to accumulate at the site of endothelial injury when the reagent was applied to isolated porcine blood vessels or in an ex vivo experiment using rat. In vivo MR detection of vascular endothelial injury was also successful in rat with its common carotid artery injured by balloon treatment. These results indicate that EB-DTPA-Gd is potentially useful for the diagnosis of vascular diseases.",

keywords = "Cardiovascular disease, MRI, MRI contrast agent, Vascular endothelial injury",

author = "Tatsuhiro Yamamoto and Kenjiro Ikuta and Keiji Oi and Kohtaro Abe and Toyokazu Uwatoku and Fuminori Hyodo and Masaharu Murata and Noboru Shigetani and Kengo Yoshimitsu and Hiroaki Shimokawa and Hideo Utsumi and Yoshiki Katayama",

note = "Funding Information: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and also from the Ministry of Health, Labour, and Welfare of Japan.",

year = "2004",

month = jun,

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doi = "10.1016/j.bmcl.2004.03.066",

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AU - Yamamoto, Tatsuhiro

AU - Ikuta, Kenjiro

AU - Oi, Keiji

AU - Abe, Kohtaro

AU - Uwatoku, Toyokazu

AU - Hyodo, Fuminori

AU - Murata, Masaharu

AU - Shigetani, Noboru

AU - Yoshimitsu, Kengo

AU - Shimokawa, Hiroaki

AU - Utsumi, Hideo

AU - Katayama, Yoshiki

N1 - Funding Information: This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and also from the Ministry of Health, Labour, and Welfare of Japan.

PY - 2004/6/7

Y1 - 2004/6/7

N2 - A new class of dye-based MRI contrast agents, EB-DTPA-Gd, was designed and synthesized. The contrast agent was found to accumulate at the site of endothelial injury when the reagent was applied to isolated porcine blood vessels or in an ex vivo experiment using rat. In vivo MR detection of vascular endothelial injury was also successful in rat with its common carotid artery injured by balloon treatment. These results indicate that EB-DTPA-Gd is potentially useful for the diagnosis of vascular diseases.

AB - A new class of dye-based MRI contrast agents, EB-DTPA-Gd, was designed and synthesized. The contrast agent was found to accumulate at the site of endothelial injury when the reagent was applied to isolated porcine blood vessels or in an ex vivo experiment using rat. In vivo MR detection of vascular endothelial injury was also successful in rat with its common carotid artery injured by balloon treatment. These results indicate that EB-DTPA-Gd is potentially useful for the diagnosis of vascular diseases.

KW - Cardiovascular disease

KW - MRI

KW - MRI contrast agent

KW - Vascular endothelial injury

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UR - https://www.scopus.com/pages/publications/2342643581#tab=citedBy

U2 - 10.1016/j.bmcl.2004.03.066

DO - 10.1016/j.bmcl.2004.03.066

M3 - Article

C2 - 15125933

AN - SCOPUS:2342643581

SN - 0960-894X

VL - 14

SP - 2787

EP - 2790

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 11

ER -

In vivo MR detection of vascular endothelial injury using a new class of MRI contrast agent

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!!!All Science Journal Classification (ASJC) codes

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