Immediate Relief of Spontaneous Coronary Artery Spasm by Intracoronary Infusion of an Endothelium-dependent Vasodilator, Substance P

This report describes a 45-year-old Japanese man who had episodes of anginal chest pain on effort. Coronary arteriography in the baseline state revealed subtotal occlusion in the mid-portion of the left anterior descending coronary artery. After intracoronary infusion of an endothelium-dependent vasodilator, substance P, the subtotal occlusion was immediately abolished. We concluded that endothelium-dependent vasodilation evoked with substance P was present at die site where coronary vasospasm occurred spontaneously in our case. (Jpn Heart J 36: 111-114, 1995).