TY - JOUR
T1 - IL-10 inhibits prostaglandin E2 production by lipopolysaccharide-stimulated monocytes
AU - Niiro, Hiroaki
AU - Otsuka, Takeshi
AU - Kuga, Seiji
AU - Nemoto, Yoshiaki
AU - Abe, Masayoshi
AU - Hara, Nobuyuki
AU - Nakano, Teruaki
AU - Ogo, Tomonori
AU - Niho, Yoshlyuki
N1 - Funding Information:
The authors thank Drs Sboehi Inaba and Kei Ikeda for helpful discussion, and Miss Leanne Bourassa (Harvard English School) for proofreading the English used in this manuscript. This work was supported in part by grants-in-aid for Scientific Research on Priority Area (nos 02256102 and 03252102) from the Ministry of Education, Science and Culture of Japan, and Uehara Memorial Foundation.
PY - 1994/4
Y1 - 1994/4
N2 - Since IL-10 has recently been shown to exhibit plelotroplc effects on human monocytes, It was of interest to determine the effect of this cytoklne on prostaglandin E2 (PGEJ production by monocytes. Recomblnant IL-10 (rlL-10) did not significantly affect PGE2 production by lipopolysaccharide (LPS)-unstimulated monocytes, but efficiently inhibited PGE2 production by LPS-stlmulated monocytes. The inhibition by rlL-10 was achieved in a dose-dependent manner. Recombinant IL-4 also inhibited PGE2 production at the same degree as rlL-10. Viral IL-10 Inhibited PGE2 production by monocytes in a similar fashion as did human rlL-10. Endogenously produced IL-10 was also shown to inhibit PGE2 production by LPS-stlmulated monocytes. Kinetic studies showed that the inhibition by rlL-10 on PGE2 production was observed at least 3 h after LPS stimulation. Taken together, these results indicate that IL-10 may play an important role in modulating immunologlcal responses via down-regulation of PGE2 production by monocytes.
AB - Since IL-10 has recently been shown to exhibit plelotroplc effects on human monocytes, It was of interest to determine the effect of this cytoklne on prostaglandin E2 (PGEJ production by monocytes. Recomblnant IL-10 (rlL-10) did not significantly affect PGE2 production by lipopolysaccharide (LPS)-unstimulated monocytes, but efficiently inhibited PGE2 production by LPS-stlmulated monocytes. The inhibition by rlL-10 was achieved in a dose-dependent manner. Recombinant IL-4 also inhibited PGE2 production at the same degree as rlL-10. Viral IL-10 Inhibited PGE2 production by monocytes in a similar fashion as did human rlL-10. Endogenously produced IL-10 was also shown to inhibit PGE2 production by LPS-stlmulated monocytes. Kinetic studies showed that the inhibition by rlL-10 on PGE2 production was observed at least 3 h after LPS stimulation. Taken together, these results indicate that IL-10 may play an important role in modulating immunologlcal responses via down-regulation of PGE2 production by monocytes.
UR - https://www.scopus.com/pages/publications/0028218201
UR - https://www.scopus.com/pages/publications/0028218201#tab=citedBy
U2 - 10.1093/intimm/6.4.661
DO - 10.1093/intimm/6.4.661
M3 - Article
C2 - 8018602
AN - SCOPUS:0028218201
SN - 0953-8178
VL - 6
SP - 661
EP - 664
JO - International immunology
JF - International immunology
IS - 4
ER -