Identifying viral parameters from in vitro cell cultures

Shingo Iwami, Kei Sato, Rob J. De Boer, Kazuyuki Aihara, Tomoyuki Miura, Yoshio Koyanagi

研究成果: ジャーナルへの寄稿学術誌査読

31 被引用数 (Scopus)


Current in vitro cell culture studies of viral replication deliver detailed time courses of several virological variables, like the amount of virions and the number of target cells, measured over several days of the experiment. Each of these time points solely provides a snap-shot of the virus infection kinetics and is brought about by the complex interplay of target cell infection, and viral production and cell death. It remains a challenge to interpret these data quantitatively and to reveal the kinetics of these underlying processes to understand how the viral infection depends on these kinetic properties. In order to decompose the kinetics of virus infection, we introduce a method to "quantitatively" describe the virus infection in in vitro cell cultures, and discuss the potential of the mathematical based analyses for experimental virology. 2012 Iwami, Sato, De Boer, Aihara, MiuraandKoyanagi.

ジャーナルFrontiers in Microbiology
出版ステータス出版済み - 2012

!!!All Science Journal Classification (ASJC) codes

  • 微生物学
  • 微生物学(医療)


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