Histamine increases the Ca current in guinea-pig ventricular myocytes

Ikunobu Muramatsu; Mami Noda; Matomo Nishio; Shigeru Kigoshi

doi:10.1016/0014-2999(87)90442-0

Histamine increases the Ca current in guinea-pig ventricular myocytes

Ikunobu Muramatsu
, Mami Noda
, Matomo Nishio
, Shigeru Kigoshi

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

6 被引用数 (Scopus)

抄録

Histamine prolonged the action potential duration and shifted the plateau in an upward direction in guinea-pig ventricular myocytes. Whole cell voltage clamp experiments revealed that histamine increases the amplitude of the inward Ca current with a slight increase in the outward current. Cimetidine but not mepyramine inhibited the effects of histamine. We suggest that histamine increases the Ca current via the mediation of the H₂-receptors.

本文言語	英語
ページ（範囲）	269-272
ページ数	4
ジャーナル	European Journal of Pharmacology
巻	138
号	2
DOI	https://doi.org/10.1016/0014-2999(87)90442-0
出版ステータス	出版済み - 6月 19 1987
外部発表	はい

!!!All Science Journal Classification (ASJC) codes

薬理学

文献へのアクセス

10.1016/0014-2999(87)90442-0

他のファイルとリンク

引用スタイル

@article{76dd4cc193f04d8e93b4cdea7a738139,

title = "Histamine increases the Ca current in guinea-pig ventricular myocytes",

abstract = "Histamine prolonged the action potential duration and shifted the plateau in an upward direction in guinea-pig ventricular myocytes. Whole cell voltage clamp experiments revealed that histamine increases the amplitude of the inward Ca current with a slight increase in the outward current. Cimetidine but not mepyramine inhibited the effects of histamine. We suggest that histamine increases the Ca current via the mediation of the H2-receptors.",

author = "Ikunobu Muramatsu and Mami Noda and Matomo Nishio and Shigeru Kigoshi",

note = "Funding Information: The authors thank M. Ohara for reading the manuscript and Naomi Yamada for secretarial assistance. Tlus work was supported m part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture, Japan.",

year = "1987",

month = jun,

day = "19",

doi = "10.1016/0014-2999(87)90442-0",

language = "English",

volume = "138",

pages = "269--272",

journal = "European Journal of Pharmacology",

issn = "0014-2999",

publisher = "Elsevier B.V.",

number = "2",

}

TY - JOUR

T1 - Histamine increases the Ca current in guinea-pig ventricular myocytes

AU - Muramatsu, Ikunobu

AU - Noda, Mami

AU - Nishio, Matomo

AU - Kigoshi, Shigeru

N1 - Funding Information: The authors thank M. Ohara for reading the manuscript and Naomi Yamada for secretarial assistance. Tlus work was supported m part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture, Japan.

PY - 1987/6/19

Y1 - 1987/6/19

N2 - Histamine prolonged the action potential duration and shifted the plateau in an upward direction in guinea-pig ventricular myocytes. Whole cell voltage clamp experiments revealed that histamine increases the amplitude of the inward Ca current with a slight increase in the outward current. Cimetidine but not mepyramine inhibited the effects of histamine. We suggest that histamine increases the Ca current via the mediation of the H2-receptors.

AB - Histamine prolonged the action potential duration and shifted the plateau in an upward direction in guinea-pig ventricular myocytes. Whole cell voltage clamp experiments revealed that histamine increases the amplitude of the inward Ca current with a slight increase in the outward current. Cimetidine but not mepyramine inhibited the effects of histamine. We suggest that histamine increases the Ca current via the mediation of the H2-receptors.

UR - https://www.scopus.com/pages/publications/0023244135

UR - https://www.scopus.com/pages/publications/0023244135#tab=citedBy

U2 - 10.1016/0014-2999(87)90442-0

DO - 10.1016/0014-2999(87)90442-0

M3 - Article

C2 - 2442005

AN - SCOPUS:0023244135

SN - 0014-2999

VL - 138

SP - 269

EP - 272

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 2

ER -

Histamine increases the Ca current in guinea-pig ventricular myocytes

抄録

!!!All Science Journal Classification (ASJC) codes

文献へのアクセス

他のファイルとリンク

フィンガープリント

引用スタイル