Herpes zoster in children with bone marrow transplantation: Report from a single institution

HIDEKI NAKAYAMA, JUN OKAMURA, SHOUICHI OHGA, CHIAKI MIYAZAKI, AKINOBU MATSUZAKI, YOSHIKO IKUNO, KOHJI UEDA, HIDEKO TASAKA

研究成果: ジャーナルへの寄稿学術誌査読

13 被引用数 (Scopus)

抄録

Herpes zoster (HZ) has been often observed after bone marrow transplantation (BMT) in childhood. The occurrence of HZ was reviewed in children who received BMT. The clinical features of HZ were reviewed in 44 children who underwent BMT at Kyushu Cancer Center. Among the 35 recipients with a history of varicella before BMT, several factors associated with BMT and the lymphocyte subsets were compared between the patients who developed HZ (HZ + group) and those who did not (HZ‐ group). Twenty‐two recipients (50%) developed HZ; in two‐thirds of these cases (15/22: 68%), HZ occurred between 80 and 120 days after BMT (median 101 days). The recipients treated with busulfan had a higher occurrence of HZ than those treated without it. The patients with Grade II‐IV acute graft‐versus‐host disease (GVHD) developed HZ more frequently. In the HZ + group, the absolute number of lymphocytes, CD3+, CD4+ or CD8+ cells at 3 months was significantly lower than that observed at 12 months after BMT and the CD4/CD8 ratio was significantly lower at 1 month than after 3 months of BMT. In conclusion, recipients were susceptible to HZ at around 100 days after BMT. The development of HZ may be associated with unbalanced T lymphocytes at that time. 1995 Japan Pediatric Society

本文言語英語
ページ(範囲)302-307
ページ数6
ジャーナルPediatrics International
37
3
DOI
出版ステータス出版済み - 6月 1995

!!!All Science Journal Classification (ASJC) codes

  • 小児科学、周産期医学および子どもの健康

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