Granular honeycomb scaffolds composed of carbonate apatite for simultaneous intra- and inter-granular osteogenesis and angiogenesis

Koichiro Hayashi; Toshiki Yanagisawa; Masaya Shimabukuro; Ryo Kishida; Kunio Ishikawa

doi:10.1016/j.mtbio.2022.100247

Granular honeycomb scaffolds composed of carbonate apatite for simultaneous intra- and inter-granular osteogenesis and angiogenesis

Koichiro Hayashi, Toshiki Yanagisawa, Masaya Shimabukuro, Ryo Kishida, Kunio Ishikawa

口腔機能修復学

研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

8 被引用数 (Scopus)

抄録

Granular porous calcium phosphate scaffolds are used for bone regeneration in dentistry. However, in conventional granules, the macropore interconnectivity is poor and has varying size. Herein, we developed a productive method for fabricating carbonate apatite honeycomb granules with uniformly sized macropores based on extrusion molding. Each honeycomb granule possesses three hexagonal macropores of ∼290 μm along its diagonal. Owing to these macropores, honeycomb granules simultaneously formed new and mature bone and blood vessels in both the interior and exterior of the granules at 4 weeks after implantation. The honeycomb granules are useful for achieving rapid osteogenesis and angiogenesis.

本文言語	英語
論文番号	100247
ジャーナル	Materials Today Bio
巻	14
DOI	https://doi.org/10.1016/j.mtbio.2022.100247
出版ステータス	出版済み - 3月 2022

!!!All Science Journal Classification (ASJC) codes

バイオテクノロジー
バイオエンジニアリング
生体材料
生体医工学
分子生物学
細胞生物学

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10.1016/j.mtbio.2022.100247

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引用スタイル

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abstract = "Granular porous calcium phosphate scaffolds are used for bone regeneration in dentistry. However, in conventional granules, the macropore interconnectivity is poor and has varying size. Herein, we developed a productive method for fabricating carbonate apatite honeycomb granules with uniformly sized macropores based on extrusion molding. Each honeycomb granule possesses three hexagonal macropores of ∼290 μm along its diagonal. Owing to these macropores, honeycomb granules simultaneously formed new and mature bone and blood vessels in both the interior and exterior of the granules at 4 weeks after implantation. The honeycomb granules are useful for achieving rapid osteogenesis and angiogenesis.",

author = "Koichiro Hayashi and Toshiki Yanagisawa and Masaya Shimabukuro and Ryo Kishida and Kunio Ishikawa",

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AU - Shimabukuro, Masaya

AU - Kishida, Ryo

AU - Ishikawa, Kunio

N1 - Funding Information: The authors acknowledge financial supports from the Japan Agency for Medical Research and Development (AMED) and Japan Society for the Promotion of Science ( JSPS ). Funding Information: This study was supported by the AMED [Grant Numbers JP21im0502004h and JP21he0422005j ] and JSPS [Grant Number JP19K22970 and JP21K17010 ]. Publisher Copyright: © 2022

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