Giant cell tumor of bone of the first rib successfully treated with combined preoperative denosumab therapy and surgery via a transmanubrial approach

Patient: Female, 27-year-old Final Diagnosis: Giant cell tumor of bone Symptoms: No symptom Medication: — Clinical Procedure: — Specialty: Oncology Objective: Background: Case Report: Conclusions: Rare disease Giant cell tumor of bone (GCTB) is a locally aggressive, intermediate tumor that rarely metastasizes. GCTB typically affects the ends of long bones and rarely involves the ribs. Curettage is typically the treatment of choice for GCTB in long bones. However, the optimal treatment of GCTB in ribs remains unclear. We report the case of a patient with asymptomatic GCTB of the first rib that was successfully treated with combined preoperative denosumab therapy and surgery via a transmanubrial approach without resection of the clavicle. A healthy 27-year-old woman presented with a bone tumor involving the left first rib that was incidentally dis-covered on routine chest X-ray. Histological examination of core-needle biopsy specimens of the lesion led to a pathological diagnosis of GCTB. After preoperative denosumab treatment for 6 months, en bloc resection via a transmanubrial approach was performed. There were no serious postoperative complications. The patient re-mained free of symptoms and had no recurrence 4.5 years after surgery. Compared with other ribs, masses located in the first rib can be challenging to treat surgically because of the clavicle and neighboring neurovascular structures. This report is the first to describe GCTB located on the anterior aspect of the first rib that was successfully treated with combined preoperative denosumab therapy and surgery via a transmanubrial approach, with no recurrence or functional impairment of the shoulder girdle.