TY - JOUR
T1 - Genome-wide association study reveals BET1L associated with survival time in the 137,693 Japanese individuals
AU - The Biobank Japan Project
AU - Akiyama, Masato
AU - Sakaue, Saori
AU - Takahashi, Atsushi
AU - Ishigaki, Kazuyoshi
AU - Hirata, Makoto
AU - Matsuda, Koichi
AU - Momozawa, Yukihide
AU - Okada, Yukinori
AU - Ninomiya, Toshiharu
AU - Koido, Masaru
AU - Morisaki, Takayuki
AU - Nagai, Akiko
AU - Sagiya, Yoji
AU - Terao, Chikashi
AU - Murakami, Yoshinori
AU - Kubo, Michiaki
AU - Kamatani, Yoichiro
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023/12
Y1 - 2023/12
N2 - Human lifespan is reported to be heritable. Although previous genome-wide association studies (GWASs) have identified several loci, a limited number of studies have assessed the genetic associations with the real survival information on the participants. We conducted a GWAS to identify loci associated with survival time in the Japanese individuals participated in the BioBank Japan Project by carrying out sex-stratified GWASs involving 78,029 males and 59,664 females. Of them, 31,324 (22.7%) died during the mean follow-up period of 7.44 years. We found a novel locus associated with survival (BET1L; P = 5.89 × 10−9). By integrating with eQTL data, we detected a significant overlap with eQTL of BET1L in skeletal muscle. A gene-set enrichment analysis showed that genes related to the BCAR1 protein–protein interaction subnetwork influence survival time (P = 1.54 × 10−7). These findings offer the candidate genes and biological mechanisms associated with human lifespan.
AB - Human lifespan is reported to be heritable. Although previous genome-wide association studies (GWASs) have identified several loci, a limited number of studies have assessed the genetic associations with the real survival information on the participants. We conducted a GWAS to identify loci associated with survival time in the Japanese individuals participated in the BioBank Japan Project by carrying out sex-stratified GWASs involving 78,029 males and 59,664 females. Of them, 31,324 (22.7%) died during the mean follow-up period of 7.44 years. We found a novel locus associated with survival (BET1L; P = 5.89 × 10−9). By integrating with eQTL data, we detected a significant overlap with eQTL of BET1L in skeletal muscle. A gene-set enrichment analysis showed that genes related to the BCAR1 protein–protein interaction subnetwork influence survival time (P = 1.54 × 10−7). These findings offer the candidate genes and biological mechanisms associated with human lifespan.
UR - http://www.scopus.com/inward/record.url?scp=85147452285&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85147452285&partnerID=8YFLogxK
U2 - 10.1038/s42003-023-04491-0
DO - 10.1038/s42003-023-04491-0
M3 - Article
C2 - 36737517
AN - SCOPUS:85147452285
SN - 2399-3642
VL - 6
JO - Communications Biology
JF - Communications Biology
IS - 1
M1 - 143
ER -