Genetic and environmental factors underlying the rapid changes in epidemiological and clinical features of multiple sclerosis and neuromyelitis optica in Japanese

Jun Ichi Kira

研究成果: ジャーナルへの寄稿総説査読

8 被引用数 (Scopus)

抄録

The discovery of a specific biomarker for neuromyelitis optica (NMO), NMO-immunoglobulin G (IgG)/anti-aquaporin-4 (AQP4) antibody, requires us to take it into account when interpreting epidemiological findings on multiple sclerosis (MS). Recent genetic studies showed that HLA-DRB1*0405 is the most common susceptibility allele for non-NMO MS in Japanese, and that DRB1*0405 carriers comprise >40% of all Japanese MS patients. Thus, idiopathic central nervous system demyelinating disease in Japanese can be subclassified into DRB1*0405-positive and -negative MS, and anti-AQP4 antibody-positive and -negative NMO. HLA-DRB1*0405-positive MS patients show younger age at onset, fewer brain lesions and a slower progression. The recent increase in the numbers of MS patients in this subgroup could explain the decrease in age at onset, as shown by the fourth nationwide survey in Japanese MS patients. Among HLA-DRB1*0405-negative MS patients, DRB1*1501 is a risk factor for MS, and DRB1*1501 carriers have high frequencies of brain lesions fulfilling the Barkhof criteria and cerebrospinal fluid IgG abnormalities. HLA-DRB1*0405-negative MS patients have higher frequencies of Epstein-Barr virus infection, but a lower frequency of Helicobacter pylori infection, which reflects improved sanitation in childhood. Anti-AQP4 antibody-positive NMO is associated with H. pylori and Chlamydia pneumoniae infections. The effects of improved sanitation on this subgroup might explain the decrease in incidence of opticospinal MS with longitudinally extensive spinal cord lesions, regarded as the same disease as NMO, as suggested by the fourth nationwide survey. Therefore, changes in environmental factors could have differentially influenced susceptibility to each disease subtype in Japanese.

本文言語英語
ページ(範囲)261-273
ページ数13
ジャーナルClinical and Experimental Neuroimmunology
4
3
DOI
出版ステータス出版済み - 12月 2013

!!!All Science Journal Classification (ASJC) codes

  • 神経科学(その他)
  • 免疫学
  • 免疫学および微生物学(その他)
  • 臨床神経学

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